Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1108101..1108933 Replicon chromosome
Accession NC_011206
Organism Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)


Gene name yhaV Uniprot ID B7J9L0
Locus tag LFERR_RS05665 Protein ID WP_009569577.1
Coordinates 1108101..1108607 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7J9L1
Locus tag LFERR_RS05670 Protein ID WP_009569578.1
Coordinates 1108604..1108933 (-) Length 110 a.a.

Genomic Context

LFERR_RS05645LFERR_RS05650LFERR_RS05655LFERR_RS05660LFERR_RS15605LFERR_RS05705LFERR_RS05665LFERR_RS05670LFERR_RS05675LFERR_RS05680LFERR_RS05685LFERR_RS05690LFERR_RS05695LFERR_RS05700
Location: 1104006..1104824 (819 bp)
Type: Others
Protein ID: Protein_1117
Location: 1104805..1105776 (972 bp)
Type: Others
Protein ID: WP_049759457.1
Location: 1105778..1106548 (771 bp)
Type: Others
Protein ID: WP_012536502.1
Location: 1106541..1107383 (843 bp)
Type: Others
Protein ID: WP_012536503.1
Location: 1109220..1109363 (144 bp)
Type: Others
Protein ID: WP_009569579.1
Location: 1112903..1113148 (246 bp)
Type: Others
Protein ID: WP_009568482.1
Location: 1108101..1108607 (507 bp)
Type: Toxin
Protein ID: WP_009569577.1
Location: 1108604..1108933 (330 bp)
Type: Antitoxin
Protein ID: WP_009569578.1
Location: 1109390..1109656 (267 bp)
Type: Others
Protein ID: WP_012536504.1
Location: 1110001..1110495 (495 bp)
Type: Others
Protein ID: WP_009565062.1
Location: 1110492..1110764 (273 bp)
Type: Others
Protein ID: WP_012536505.1
Location: 1110845..1111057 (213 bp)
Type: Others
Protein ID: WP_009562915.1
Location: 1111225..1111441 (217 bp)
Type: Others
Protein ID: Protein_1128
Location: 1111841..1112662 (822 bp)
Type: Others
Protein ID: WP_012536506.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFERR_RS056451104006..1104824+819Protein_1117UDP-glucose/GDP-mannose dehydrogenase family protein-
LFERR_RS056501104805..1105776+972WP_049759457.1D-glycero-beta-D-manno-heptose-7-phosphate kinase-
LFERR_RS056551105778..1106548+771WP_012536502.1tRNA 2-thiocytidine(32) synthetase TtcA-
LFERR_RS056601106541..1107383+843WP_012536503.1Hsp33 family molecular chaperone HslO-
LFERR_RS056651108101..1108607-507WP_009569577.1type II toxin-antitoxin system YhaV family toxinToxin
LFERR_RS056701108604..1108933-330WP_009569578.1type II toxin-antitoxin system PrlF family antitoxinAntitoxin
LFERR_RS156051109220..1109363+144WP_009569579.1hypothetical protein-
LFERR_RS056751109390..1109656-267WP_012536504.1type I restriction-modification system subunit M N-terminal domain-containing protein-
LFERR_RS056801110001..1110495-495WP_009565062.1GNAT family N-acetyltransferase-
LFERR_RS056851110492..1110764-273WP_012536505.1DUF1778 domain-containing protein-
LFERR_RS056901110845..1111057-213WP_009562915.1hypothetical protein-
LFERR_RS056951111225..1111441-217Protein_1128hypothetical protein-
LFERR_RS057001111841..1112662-822WP_012536506.1UDP-2,3-diacylglucosamine diphosphatase-
LFERR_RS057051112903..1113148+246WP_009568482.1DUF2934 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 19373.17 Da        Isoelectric Point: 9.9366

>T23070 WP_009569577.1 NC_011206:c1108607-1108101 [Acidithiobacillus ferrooxidans ATCC 53993]
MSSSKLAPLVIHGWTVFAHPLFLAHIETLAQQVEAFKKKDPVGYVKKNANKRLAAIIKLAFDAIPQDPTRPEYRQGNTLG
EDHKHWFRAKFFQQYRLFFRYHAPSKVIVLAWVNDEDTKRAYESSDDAYRVFRKMLESGRPPDDWNQLLAEACAEGQRLQ
RFAAGIAP

Download         Length: 507 bp

>T23070 NC_011206:c1108607-1108101 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGAGCTCGAGCAAGCTCGCGCCCTTGGTCATTCATGGCTGGACGGTTTTTGCCCACCCGCTATTCCTCGCGCATATTGA
GACCTTGGCCCAGCAGGTCGAGGCCTTCAAGAAAAAGGATCCCGTCGGATACGTGAAAAAGAACGCCAATAAGCGACTGG
CGGCGATCATCAAACTGGCGTTCGACGCCATCCCGCAAGACCCGACACGGCCAGAGTACCGTCAAGGCAACACCCTCGGT
GAAGATCACAAGCACTGGTTCCGCGCCAAGTTTTTCCAGCAATACCGGCTGTTCTTCCGCTACCACGCGCCGAGCAAGGT
GATCGTGCTCGCCTGGGTCAATGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGACGACGCCTATCGGGTGTTCCGAA
AGATGCTGGAAAGCGGCCGTCCTCCGGATGACTGGAACCAGTTGCTGGCCGAGGCATGCGCCGAGGGGCAGCGACTACAG
CGATTCGCTGCTGGCATTGCACCGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12107.54 Da        Isoelectric Point: 4.3141

>AT23070 WP_009569578.1 NC_011206:c1108933-1108604 [Acidithiobacillus ferrooxidans ATCC 53993]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEDSEEDDPVLGQFLGFLARDIATHPERLQA
IDVSFVQRLQSLTGGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT23070 NC_011206:c1108933-1108604 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGGCTGCCACCCTCGAAGTCGAATCCACGCTGACTGACCGCTACCAAACCACGGTGCCGGAGACCGTCCGCCGGGCCCT
CCGGCTGGGCAAGCGCGACAAGATCCACTACACCATCCGCCCCGGTGGCGAGGTCGTGCTGACGCGCGCCGAGGACTCCG
AGGAAGACGATCCGGTGCTCGGTCAGTTCCTGGGCTTCCTGGCCCGCGACATCGCCACGCATCCAGAGCGCCTGCAGGCC
ATCGATGTCAGCTTCGTGCAGCGCCTCCAATCGCTGACCGGCGGCATCGAAGTCGATCTCGATGCCCCCTTGTCTGCGGA
CGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB7J9L0

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J9L1

References