Detailed information of TA system TA230696

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2300226..2300424
• Replicon: chromosome
• Accession: NZ_CP090407
• Organism: Staphylococcus aureus strain GD4SA159-1

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LZ183_RS11335
• Protein ID: WP_001802298.1
• Coordinates: 2300320..2300424 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2300226..2300264 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ183_RS11310 (LZ183_11290)	2296346..2297011	-	666	WP_001024099.1	SDR family oxidoreductase	-
LZ183_RS11315 (LZ183_11295)	2297163..2297483	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LZ183_RS11320 (LZ183_11300)	2297485..2298465	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
LZ183_RS11325 (LZ183_11305)	2298731..2299822	+	1092	WP_000495673.1	hypothetical protein	-
LZ183_RS11330 (LZ183_11310)	2300206..2300280	+	75	Protein_2192	hypothetical protein	-
-	2300226..2300264	+	39	-	-	Antitoxin
LZ183_RS11335 (LZ183_11315)	2300320..2300424	-	105	WP_001802298.1	hypothetical protein	Toxin
LZ183_RS11340 (LZ183_11320)	2301104..2301262	+	159	WP_001792784.1	hypothetical protein	-
LZ183_RS11345 (LZ183_11325)	2301698..2301790	+	93	WP_000220902.1	hypothetical protein	-
LZ183_RS11350 (LZ183_11330)	2301920..2302777	-	858	WP_000370942.1	HAD family hydrolase	-
LZ183_RS11355 (LZ183_11335)	2302845..2303627	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
LZ183_RS11360 (LZ183_11340)	2303917..2304525	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T230696 WP_001802298.1 NZ_CP090407:c2300424-2300320 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T230696 NZ_CP125334:874037-874444 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT230696 NZ_CP090407:2300226-2300264 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin