Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 396292..396871 | Replicon | chromosome |
| Accession | NZ_CP090407 | ||
| Organism | Staphylococcus aureus strain GD4SA159-1 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | LZ183_RS01815 | Protein ID | WP_001025401.1 |
| Coordinates | 396292..396537 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 396506..396871 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ183_RS01755 (LZ183_01750) | 391818..391964 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| LZ183_RS01760 (LZ183_01755) | 392194..392778 | - | 585 | WP_000825948.1 | hypothetical protein | - |
| LZ183_RS01765 (LZ183_01760) | 392796..393257 | - | 462 | WP_000525004.1 | hypothetical protein | - |
| LZ183_RS01770 (LZ183_01765) | 393270..393584 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| LZ183_RS01775 (LZ183_01770) | 393736..393972 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| LZ183_RS01780 (LZ183_01775) | 393986..394762 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| LZ183_RS01785 (LZ183_01780) | 394791..394934 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| LZ183_RS01790 (LZ183_01785) | 394924..395133 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| LZ183_RS01795 (LZ183_01790) | 395189..395338 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| LZ183_RS01800 (LZ183_01795) | 395379..395591 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| LZ183_RS01805 (LZ183_01800) | 395661..395858 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| LZ183_RS01810 (LZ183_01805) | 395845..396225 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| LZ183_RS01815 (LZ183_01810) | 396292..396537 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| LZ183_RS01820 (LZ183_01815) | 396506..396871 | - | 366 | WP_001128432.1 | hypothetical protein | Antitoxin |
| LZ183_RS01825 (LZ183_01820) | 396926..397141 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| LZ183_RS01830 (LZ183_01825) | 397166..397429 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| LZ183_RS01835 (LZ183_01830) | 397442..397603 | + | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| LZ183_RS01840 (LZ183_01835) | 397682..398005 | + | 324 | WP_000175000.1 | hypothetical protein | - |
| LZ183_RS01845 (LZ183_01840) | 398020..398382 | + | 363 | WP_000985986.1 | hypothetical protein | - |
| LZ183_RS01850 (LZ183_01845) | 398379..399545 | + | 1167 | WP_000762545.1 | DUF2800 domain-containing protein | - |
| LZ183_RS01855 (LZ183_01850) | 399571..400128 | + | 558 | WP_000645045.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | dfrG | - | 389876..436563 | 46687 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T230689 WP_001025401.1 NZ_CP090407:396292-396537 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T230689 NZ_CP125315:c446654-446367 [Lacticaseibacillus rhamnosus]
ATGATGTTGACGATTAATCGCACGCGCACTTTCAAACGACAATTTAAACATCTTCTTAGGCAAGGTAAAGATATGACGAA
ACTTGCAACTGCAATTGATACTTTGCAGCGTCAAGATCGTGTGAAATTAGCTTCTTTACACGACCATGCTTTAAAGGGTG
CTCACAGCGGCGAACGAGCATTGCATGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTA
ATGCTTCTTGCAACAGGCACACACCGCGATACATTGAACATTGAGTAA
ATGATGTTGACGATTAATCGCACGCGCACTTTCAAACGACAATTTAAACATCTTCTTAGGCAAGGTAAAGATATGACGAA
ACTTGCAACTGCAATTGATACTTTGCAGCGTCAAGATCGTGTGAAATTAGCTTCTTTACACGACCATGCTTTAAAGGGTG
CTCACAGCGGCGAACGAGCATTGCATGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTA
ATGCTTCTTGCAACAGGCACACACCGCGATACATTGAACATTGAGTAA
Antitoxin
Download Length: 366 bp
>AT230689 NZ_CP090407:c396871-396506 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAAAACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAAAACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
