Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4542231..4542833 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LXH19_RS21420 Protein ID WP_024046152.1
Coordinates 4542522..4542833 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXH19_RS21415 Protein ID WP_000356395.1
Coordinates 4542231..4542521 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS21380 (4537855) 4537855..4538757 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LXH19_RS21385 (4538754) 4538754..4539389 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LXH19_RS21390 (4539386) 4539386..4540315 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
LXH19_RS21395 (4540497) 4540497..4540739 - 243 WP_001309881.1 CopG family transcriptional regulator -
LXH19_RS21400 (4540958) 4540958..4541176 - 219 WP_001295676.1 CopG family transcriptional regulator -
LXH19_RS21405 (4541595) 4541595..4541873 - 279 WP_001315112.1 hypothetical protein -
LXH19_RS21410 (4541925) 4541925..4542146 - 222 WP_001550354.1 hypothetical protein -
LXH19_RS21415 (4542231) 4542231..4542521 - 291 WP_000356395.1 NadS family protein Antitoxin
LXH19_RS21420 (4542522) 4542522..4542833 - 312 WP_024046152.1 hypothetical protein Toxin
LXH19_RS21425 (4543062) 4543062..4543970 + 909 WP_001550353.1 alpha/beta hydrolase -
LXH19_RS21430 (4545065) 4545065..4545952 - 888 Protein_4179 hypothetical protein -
LXH19_RS21435 (4546368) 4546368..4547309 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LXH19_RS21440 (4547354) 4547354..4547791 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12130.16 Da        Isoelectric Point: 9.5486

>T230676 WP_024046152.1 NZ_CP090402:c4542833-4542522 [Shigella sp. PIB]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHCEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T230676 NZ_CP125310:c2589801-2589625 [Citrobacter freundii]
GTGAAGCAAAGTAAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT230676 WP_000356395.1 NZ_CP090402:c4542521-4542231 [Shigella sp. PIB]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT230676 NZ_CP125310:c2589578-2589162 [Citrobacter freundii]
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCAGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References