Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3955793..3956051 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LXH19_RS18725 Protein ID WP_000809168.1
Coordinates 3955899..3956051 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3955793..3955850 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS18710 3952179..3953138 + 960 WP_000871682.1 hypothetical protein -
LXH19_RS18715 3953176..3954075 - 900 WP_001300855.1 transcriptional activator NhaR -
LXH19_RS18720 3954141..3955307 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3955793..3955850 - 58 - - Antitoxin
LXH19_RS18725 3955899..3956051 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
LXH19_RS18730 3956155..3957285 - 1131 WP_001118464.1 molecular chaperone DnaJ -
LXH19_RS18735 3957374..3959290 - 1917 WP_000516135.1 molecular chaperone DnaK -
LXH19_RS18740 3959666..3960070 + 405 WP_000843579.1 DUF2541 family protein -
LXH19_RS18745 3960096..3960809 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T230671 WP_000809168.1 NZ_CP090402:3955899-3956051 [Shigella sp. PIB]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T230671 NZ_CP125300:4121818-4122108 [Pseudomonas syringae pv. syringae]
ATGACCTTTAAGCTTGAATTTCTGCCCTCGGCCTTGAAGGAGTGGGAAAAACTGGGCCATACCATCCGTGTTCAGCTCAA
GAAAAAGCTTCTCGAACGACTCGGACTACCAAGAATTCCAGGCGATGCGCTTCATGGCATGCCAGATCATTACAAAATCA
AACTGCGCAGTGCAGGATACCGACTCGTCTATCGAGTCGAGGAAGATAGGGTAGTGGTAACCGTCGTTGCGGTAGGCAAG
CGCGAGCGCGGGAATATTTATGATTCGGCCAAAGGCAGGCTTGGCCCTTGA

Antitoxin


Download         Length: 58 bp

>AT230671 NZ_CP090402:c3955850-3955793 [Shigella sp. PIB]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References