Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1886856..1887358 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag LXH19_RS08965 Protein ID WP_000767829.1
Coordinates 1887104..1887358 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LXH19_RS08960 Protein ID WP_001259255.1
Coordinates 1886856..1887107 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS08935 (1882034) 1882034..1883101 - 1068 WP_000080080.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LXH19_RS08940 (1883101) 1883101..1884171 - 1071 WP_000108953.1 histidinol-phosphate transaminase -
LXH19_RS08945 (1884168) 1884168..1885472 - 1305 WP_206312550.1 histidinol dehydrogenase -
LXH19_RS08950 (1885478) 1885478..1886377 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LXH19_RS08955 (1886523) 1886523..1886573 - 51 WP_001364200.1 his operon leader peptide -
LXH19_RS08960 (1886856) 1886856..1887107 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LXH19_RS08965 (1887104) 1887104..1887358 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LXH19_RS08970 (1887441) 1887441..1888265 + 825 WP_000754758.1 SDR family oxidoreductase -
LXH19_RS08975 (1888311) 1888311..1889240 + 930 WP_024192945.1 LysR substrate-binding domain-containing protein -
LXH19_RS08980 (1889455) 1889455..1889517 + 63 WP_010723108.1 membrane protein YoeI -
LXH19_RS08985 (1889507) 1889507..1890865 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T230657 WP_000767829.1 NZ_CP090402:1887104-1887358 [Shigella sp. PIB]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T230657 NZ_CP125288:c4750164-4749799 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGAGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT230657 WP_001259255.1 NZ_CP090402:1886856-1887107 [Shigella sp. PIB]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT230657 NZ_CP125288:c4749806-4749483 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATCGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References