Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 634494..635293 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name yhaV Uniprot ID A0A369FDQ4
Locus tag LXH19_RS03055 Protein ID WP_000347280.1
Coordinates 634494..634958 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LXH19_RS03060 Protein ID WP_001307405.1
Coordinates 634958..635293 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS03025 (629495) 629495..629929 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LXH19_RS03030 (629947) 629947..630825 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LXH19_RS03035 (630815) 630815..631594 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LXH19_RS03040 (631605) 631605..632078 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LXH19_RS03045 (632101) 632101..633381 - 1281 WP_000681960.1 tagatose-bisphosphate aldolase subunit KbaZ -
LXH19_RS03050 (633630) 633630..634439 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
LXH19_RS03055 (634494) 634494..634958 - 465 WP_000347280.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LXH19_RS03060 (634958) 634958..635293 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LXH19_RS03065 (635442) 635442..637013 - 1572 WP_024216579.1 galactarate dehydratase -
LXH19_RS03070 (637388) 637388..638722 + 1335 WP_024046198.1 galactarate/glucarate/glycerate transporter GarP -
LXH19_RS03075 (638738) 638738..639508 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17862.29 Da        Isoelectric Point: 9.6924

>T230654 WP_000347280.1 NZ_CP090402:c634958-634494 [Shigella sp. PIB]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

>T230654 NZ_CP125288:c164358-164077 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCGACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT230654 WP_001307405.1 NZ_CP090402:c635293-634958 [Shigella sp. PIB]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT230654 NZ_CP125288:c164582-164355 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A369FDQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References