Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 745872..746647 Replicon chromosome
Accession NZ_CP090398
Organism Klebsiella pneumoniae strain F94

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LZG48_RS03730 Protein ID WP_004150910.1
Coordinates 746162..746647 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LZG48_RS03725 Protein ID WP_004150912.1
Coordinates 745872..746165 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG48_RS03705 (LZG48_03705) 741080..741682 - 603 WP_062954968.1 short chain dehydrogenase -
LZG48_RS03710 (LZG48_03710) 741780..742691 + 912 WP_004188550.1 LysR family transcriptional regulator -
LZG48_RS03715 (LZG48_03715) 742692..743840 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
LZG48_RS03720 (LZG48_03720) 743851..745227 - 1377 WP_004217775.1 cystathionine beta-synthase -
LZG48_RS03725 (LZG48_03725) 745872..746165 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LZG48_RS03730 (LZG48_03730) 746162..746647 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LZG48_RS03735 (LZG48_03735) 747351..747944 + 594 WP_004188553.1 hypothetical protein -
LZG48_RS03740 (LZG48_03740) 748041..748257 + 217 Protein_735 transposase -
LZG48_RS03745 (LZG48_03745) 748863..749735 + 873 WP_004188557.1 ParA family protein -
LZG48_RS03750 (LZG48_03750) 749735..750118 + 384 WP_004150906.1 hypothetical protein -
LZG48_RS03755 (LZG48_03755) 750111..751478 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 748041..748193 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T230617 WP_004150910.1 NZ_CP090398:746162-746647 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T230617 NZ_CP125094:c325965-325696 [Agrobacterium fabrum]
TTGATCTGGAGAATTGAATTCCAGCGAAATGCCGTCAAGCAACTGGGCAAGCTGACGAAGAGCGATGCCAATCGCATCGT
TTCATTTCTGACGGACCGCGTTGCCCAGGACGACAATCCGCGCAGAGCCGGCGCAGCGCTGCAAGGTTCCGAGCTCGGAA
ATTTCTGGCATTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGACCACAAGCTGGTCGTTCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATTTACCGTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT230617 WP_004150912.1 NZ_CP090398:745872-746165 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT230617 NZ_CP125094:c326182-325949 [Agrobacterium fabrum]
ATGAGCAAACAGACGGCCATTCGCCTGCCGGACGAGACCTATGAGCGGCTGAAGGCGCTGTCTGAGCGGACCGGCCGCAC
ATCCGCCTATTACATCCGCGAGGCGATCGAGAAGCATATCGAGGATATGGAAGACCTCTATCTTGCCGAAGAGGCGATGC
GGAAGCACATCGCCAATAAGGAGCGCACCTATACTCTGGAAGAAGTGATGCGTGATCTTGATCTGGAGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References