Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 755492..756267 Replicon chromosome
Accession NZ_CP090393
Organism Klebsiella pneumoniae strain YZH2429

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LY283_RS03785 Protein ID WP_114263821.1
Coordinates 755782..756267 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LY283_RS03780 Protein ID WP_004150912.1
Coordinates 755492..755785 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY283_RS03760 (750700) 750700..751302 - 603 WP_004174410.1 short chain dehydrogenase -
LY283_RS03765 (751400) 751400..752311 + 912 WP_023342207.1 LysR family transcriptional regulator -
LY283_RS03770 (752312) 752312..753460 - 1149 WP_114263822.1 PLP-dependent aspartate aminotransferase family protein -
LY283_RS03775 (753471) 753471..754847 - 1377 WP_004181304.1 cystathionine beta-synthase -
LY283_RS03780 (755492) 755492..755785 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LY283_RS03785 (755782) 755782..756267 + 486 WP_114263821.1 GNAT family N-acetyltransferase Toxin
LY283_RS03790 (756971) 756971..757564 + 594 WP_004188553.1 hypothetical protein -
LY283_RS03795 (757661) 757661..757877 + 217 Protein_746 transposase -
LY283_RS03805 (758555) 758555..759268 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 757661..757813 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17611.60 Da        Isoelectric Point: 8.5144

>T230576 WP_114263821.1 NZ_CP090393:755782-756267 [Klebsiella pneumoniae]
MISAPEPLHSGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T230576 NZ_CP125083:714781-714883 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT230576 WP_004150912.1 NZ_CP090393:755492-755785 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT230576 NZ_CP125083:c714890-714745 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References