Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 755492..756267 | Replicon | chromosome |
Accession | NZ_CP090393 | ||
Organism | Klebsiella pneumoniae strain YZH2429 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | - |
Locus tag | LY283_RS03785 | Protein ID | WP_114263821.1 |
Coordinates | 755782..756267 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | LY283_RS03780 | Protein ID | WP_004150912.1 |
Coordinates | 755492..755785 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LY283_RS03760 (750700) | 750700..751302 | - | 603 | WP_004174410.1 | short chain dehydrogenase | - |
LY283_RS03765 (751400) | 751400..752311 | + | 912 | WP_023342207.1 | LysR family transcriptional regulator | - |
LY283_RS03770 (752312) | 752312..753460 | - | 1149 | WP_114263822.1 | PLP-dependent aspartate aminotransferase family protein | - |
LY283_RS03775 (753471) | 753471..754847 | - | 1377 | WP_004181304.1 | cystathionine beta-synthase | - |
LY283_RS03780 (755492) | 755492..755785 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
LY283_RS03785 (755782) | 755782..756267 | + | 486 | WP_114263821.1 | GNAT family N-acetyltransferase | Toxin |
LY283_RS03790 (756971) | 756971..757564 | + | 594 | WP_004188553.1 | hypothetical protein | - |
LY283_RS03795 (757661) | 757661..757877 | + | 217 | Protein_746 | transposase | - |
LY283_RS03805 (758555) | 758555..759268 | - | 714 | WP_002916694.1 | DUF554 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 757661..757813 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17611.60 Da Isoelectric Point: 8.5144
>T230576 WP_114263821.1 NZ_CP090393:755782-756267 [Klebsiella pneumoniae]
MISAPEPLHSGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MISAPEPLHSGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
>T230576 NZ_CP125083:714781-714883 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10901.46 Da Isoelectric Point: 6.3783
>AT230576 WP_004150912.1 NZ_CP090393:755492-755785 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
Download Length: 294 bp
>AT230576 NZ_CP125083:c714890-714745 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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