Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 1003732..1004365 | Replicon | chromosome |
| Accession | NZ_CP090386 | ||
| Organism | Vibrio cholerae strain GXFL1-4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | LY388_RS04570 | Protein ID | WP_000843587.1 |
| Coordinates | 1004033..1004365 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LY388_RS04565 | Protein ID | WP_000071010.1 |
| Coordinates | 1003732..1004046 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LY388_RS04510 (LY388_04510) | 998732..998878 | - | 147 | Protein_898 | DUF645 family protein | - |
| LY388_RS04515 (LY388_04515) | 998939..999074 | - | 136 | Protein_899 | acetyltransferase | - |
| LY388_RS04520 (LY388_04520) | 999055..999174 | - | 120 | WP_080004135.1 | DUF3265 domain-containing protein | - |
| LY388_RS04525 (LY388_04525) | 999167..999868 | - | 702 | WP_001162671.1 | HNH endonuclease | - |
| LY388_RS04530 (LY388_04530) | 999898..1000008 | - | 111 | WP_196389672.1 | DUF3265 domain-containing protein | - |
| LY388_RS04535 (LY388_04535) | 1000493..1000912 | - | 420 | WP_114808795.1 | hypothetical protein | - |
| LY388_RS04540 (LY388_04540) | 1001111..1001215 | - | 105 | WP_199358725.1 | DUF645 family protein | - |
| LY388_RS04545 (LY388_04545) | 1001185..1001286 | - | 102 | Protein_905 | DUF645 family protein | - |
| LY388_RS04550 (LY388_04550) | 1001584..1002354 | - | 771 | WP_000797384.1 | alpha/beta hydrolase | - |
| LY388_RS04555 (LY388_04555) | 1002518..1002895 | - | 378 | WP_057552762.1 | hypothetical protein | - |
| LY388_RS04560 (LY388_04560) | 1003053..1003583 | - | 531 | WP_095467805.1 | hypothetical protein | - |
| LY388_RS04565 (LY388_04565) | 1003732..1004046 | - | 315 | WP_000071010.1 | DNA-binding transcriptional regulator | Antitoxin |
| LY388_RS04570 (LY388_04570) | 1004033..1004365 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LY388_RS04575 (LY388_04575) | 1004555..1004692 | - | 138 | Protein_911 | cell shape-determining protein MreC | - |
| LY388_RS04580 (LY388_04580) | 1004667..1004720 | - | 54 | Protein_912 | DUF645 family protein | - |
| LY388_RS04585 (LY388_04585) | 1005076..1005585 | - | 510 | WP_142626918.1 | GNAT family N-acetyltransferase | - |
| LY388_RS04590 (LY388_04590) | 1005612..1005674 | - | 63 | Protein_914 | acetyltransferase | - |
| LY388_RS04595 (LY388_04595) | 1005731..1006201 | - | 471 | WP_154027101.1 | GNAT family N-acetyltransferase | - |
| LY388_RS04600 (LY388_04600) | 1006346..1007059 | - | 714 | WP_000123659.1 | Fic family protein | - |
| LY388_RS04605 (LY388_04605) | 1007313..1007491 | - | 179 | Protein_917 | DUF645 family protein | - |
| LY388_RS04610 (LY388_04610) | 1007660..1007731 | - | 72 | Protein_918 | acetyltransferase | - |
| LY388_RS04615 (LY388_04615) | 1007902..1008888 | + | 987 | WP_142578501.1 | sulfate ABC transporter substrate-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 982167..1000912 | 18745 | |
| - | inside | Integron | - | - | 992905..1075334 | 82429 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T230547 WP_000843587.1 NZ_CP090386:c1004365-1004033 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T230547 NZ_CP124921:c2774122-2773781 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACGCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACGCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 11687.19 Da Isoelectric Point: 6.6445
>AT230547 WP_000071010.1 NZ_CP090386:c1004046-1003732 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSQIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSQIAEL
Download Length: 315 bp
>AT230547 NZ_CP124921:c2774352-2774122 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|