Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2254522..2254720 Replicon chromosome
Accession NZ_CP090375
Organism Staphylococcus aureus strain GD4SA108-1

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag LZ178_RS10950 Protein ID WP_001802298.1
Coordinates 2254616..2254720 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2254522..2254560 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ178_RS10925 (LZ178_10905) 2250642..2251307 - 666 WP_001024099.1 SDR family oxidoreductase -
LZ178_RS10930 (LZ178_10910) 2251459..2251779 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
LZ178_RS10935 (LZ178_10915) 2251781..2252761 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
LZ178_RS10940 (LZ178_10920) 2253027..2254118 + 1092 WP_000495673.1 hypothetical protein -
LZ178_RS10945 (LZ178_10925) 2254502..2254576 + 75 Protein_2115 hypothetical protein -
- 2254522..2254560 + 39 - - Antitoxin
LZ178_RS10950 (LZ178_10930) 2254616..2254720 - 105 WP_001802298.1 hypothetical protein Toxin
LZ178_RS10955 (LZ178_10935) 2255400..2255558 + 159 WP_001792784.1 hypothetical protein -
LZ178_RS10960 (LZ178_10940) 2255994..2256086 + 93 WP_000220902.1 hypothetical protein -
LZ178_RS10965 (LZ178_10945) 2256216..2257073 - 858 WP_000370942.1 HAD family hydrolase -
LZ178_RS10970 (LZ178_10950) 2257141..2257923 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
LZ178_RS10975 (LZ178_10955) 2258213..2258821 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T230509 WP_001802298.1 NZ_CP090375:c2254720-2254616 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T230509 NZ_CP124913:2760422-2760517 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 39 bp

>AT230509 NZ_CP090375:2254522-2254560 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References