Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 795708..796347 Replicon chromosome
Accession NZ_CP090365
Organism Photobacterium sp. TLY01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LN341_RS19205 Protein ID WP_234205241.1
Coordinates 795708..796046 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LN341_RS19210 Protein ID WP_234205242.1
Coordinates 796033..796347 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN341_RS19175 (LN341_19175) 790979..791863 - 885 WP_234205233.1 LysR substrate-binding domain-containing protein -
LN341_RS19180 (LN341_19180) 792046..793131 + 1086 WP_234205236.1 histidinol-phosphate transaminase -
LN341_RS19185 (LN341_19185) 793165..793938 + 774 WP_046219895.1 ABC transporter substrate-binding protein -
LN341_RS19190 (LN341_19190) 794801..795025 + 225 WP_234205238.1 maltose ABC transporter permease -
LN341_RS19195 (LN341_19195) 795074..795253 - 180 Protein_708 IS110 family transposase -
LN341_RS19200 (LN341_19200) 795270..795535 - 266 Protein_709 IS110 family transposase -
LN341_RS19205 (LN341_19205) 795708..796046 + 339 WP_234205241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LN341_RS19210 (LN341_19210) 796033..796347 + 315 WP_234205242.1 DNA-binding transcriptional regulator Antitoxin
LN341_RS19215 (LN341_19215) 796887..797849 + 963 WP_234205245.1 GIY-YIG nuclease family protein -
LN341_RS19220 (LN341_19220) 798416..799527 + 1112 WP_234205030.1 IS3 family transposase -
LN341_RS19225 (LN341_19225) 799687..800535 + 849 WP_234205247.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13093.01 Da        Isoelectric Point: 10.2003

>T230499 WP_234205241.1 NZ_CP090365:795708-796046 [Photobacterium sp. TLY01]
MKSVFVESTIFEKYRSDYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKGKRGGSRVIYYFLDEKRRFYL
LTIYGKNEMSDLTVDQKKQLKAFMEAWRNEQS

Download         Length: 339 bp

>T230499 NZ_CP124911:2884269-2884412 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAAGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11782.24 Da        Isoelectric Point: 6.3297

>AT230499 WP_234205242.1 NZ_CP090365:796033-796347 [Photobacterium sp. TLY01]
MSNRDLFAELSSALVEAKEHSEGKVTLKTHQFNDISELNISPEEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSTP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT230499 NZ_CP124911:c2884606-2884344 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References