Detailed information of TA system TA230498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3029787..3030424
• Replicon: chromosome
• Accession: NZ_CP090364
• Organism: Photobacterium sp. TLY01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LN341_RS14030
• Protein ID: WP_234203631.1
• Coordinates: 3030131..3030424 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LN341_RS14025
• Protein ID: WP_234203630.1
• Coordinates: 3029787..3030116 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LN341_RS14010 (LN341_14010)	3025228..3026313	-	1086	WP_234203627.1	patatin-like phospholipase family protein	-
LN341_RS14015 (LN341_14015)	3026310..3028556	-	2247	WP_234203628.1	ThiF family adenylyltransferase	-
LN341_RS14020 (LN341_14020)	3028556..3029710	-	1155	WP_234203629.1	hypothetical protein	-
LN341_RS14025 (LN341_14025)	3029787..3030116	-	330	WP_234203630.1	HigA family addiction module antitoxin	Antitoxin
LN341_RS14030 (LN341_14030)	3030131..3030424	-	294	WP_234203631.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LN341_RS14035 (LN341_14035)	3030784..3031014	-	231	WP_095463394.1	pyocin activator PrtN family protein	-
LN341_RS14040 (LN341_14040)	3031121..3032632	-	1512	WP_234203632.1	hypothetical protein	-
LN341_RS14045 (LN341_14045)	3033332..3033736	-	405	WP_234203633.1	DUF3597 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3007949..3032632	24683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-85)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11359.86 Da
• Isoelectric Point: 4.8500

>T230498 WP_234203631.1 NZ_CP090364:c3030424-3030131 [Photobacterium sp. TLY01]
MAVEFIDTWLEAFYEDDQSHRKIPSTIESALFRKLEILDAATQESDLLIPPGNRFEHLEGNMAGWCSIRVNKQYRLIFRW
IDGVAKDTYLDPHVYRG

Nucleotide

• Length: 294 bp

>T230498 NZ_CP124911:c2877935-2877594 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12558.61 Da
• Isoelectric Point: 10.6438

>AT230498 WP_234203630.1 NZ_CP090364:c3030116-3029787 [Photobacterium sp. TLY01]
MRNTKRRPVTVGQMLVTEFLKPMNIEINELAEAMGVHRNTLSRIVHDKGALTAPMAIKLAAALGNTPEFWLNIQHSVELW
DVRHRAFEQEAKNVKRLKPNLEHREVAFH

Nucleotide

• Length: 330 bp

>AT230498 NZ_CP124911:c2878165-2877935 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA