Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4131113..4131773 Replicon chromosome
Accession NZ_CP090356
Organism Pantoea ananatis strain JBR-LB3-16

Toxin (Protein)


Gene name higB Uniprot ID D4GHT4
Locus tag LVR30_RS19380 Protein ID WP_013026313.1
Coordinates 4131420..4131773 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LVR30_RS19375 Protein ID WP_161610845.1
Coordinates 4131113..4131415 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVR30_RS19355 (LVR30_19360) 4126767..4128164 + 1398 WP_250331074.1 D-arabinono-1,4-lactone oxidase -
LVR30_RS19360 (LVR30_19365) 4128166..4128993 + 828 WP_014594033.1 glycosyltransferase family 8 protein -
LVR30_RS19365 (LVR30_19370) 4129073..4130194 - 1122 WP_250331075.1 Gfo/Idh/MocA family oxidoreductase -
LVR30_RS19375 (LVR30_19380) 4131113..4131415 - 303 WP_161610845.1 XRE family transcriptional regulator Antitoxin
LVR30_RS19380 (LVR30_19385) 4131420..4131773 - 354 WP_013026313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVR30_RS19385 (LVR30_19390) 4132057..4132371 - 315 WP_015699977.1 L-rhamnose mutarotase -
LVR30_RS19390 (LVR30_19395) 4132361..4133203 - 843 WP_013026315.1 rhamnulose-1-phosphate aldolase -
LVR30_RS19395 (LVR30_19400) 4133214..4134470 - 1257 WP_022623371.1 L-rhamnose isomerase -
LVR30_RS19400 (LVR30_19405) 4134454..4135935 - 1482 WP_015699974.1 rhamnulokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13317.24 Da        Isoelectric Point: 9.5793

>T230496 WP_013026313.1 NZ_CP090356:c4131773-4131420 [Pantoea ananatis]
VWPIKTTDTFDCWFTSLSDIDRADVLAALLVLREKGPGLSRPYADTLKGSRYSNMKERRIQSRGDPLRAFFAFDPARTGI
VLCAGNKVGNEKRFYDAMLPVADREFTNWLNALKNKE

Download         Length: 354 bp

>T230496 NZ_CP124911:c2732659-2732558 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11073.80 Da        Isoelectric Point: 5.1679

>AT230496 WP_161610845.1 NZ_CP090356:c4131415-4131113 [Pantoea ananatis]
MGRTLEQLIADEKNDVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYAFVL

Download         Length: 303 bp

>AT230496 NZ_CP124911:2732434-2732613 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4GHT4

Antitoxin

Source ID Structure

References