Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2293774..2294378 Replicon chromosome
Accession NZ_CP090355
Organism Pseudomonas kribbensis strain H38E-23

Toxin (Protein)


Gene name higB Uniprot ID Q3KJP2
Locus tag LXN51_RS10665 Protein ID WP_011331970.1
Coordinates 2294064..2294378 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXN51_RS10660 Protein ID WP_234206267.1
Coordinates 2293774..2294061 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN51_RS10635 (LXN51_10635) 2288809..2289588 - 780 WP_234206262.1 EAL domain-containing protein -
LXN51_RS10640 (LXN51_10640) 2289705..2290112 + 408 WP_085702734.1 S4 domain-containing protein -
LXN51_RS10645 (LXN51_10645) 2290178..2290978 - 801 WP_234206264.1 phosphatase PAP2 family protein -
LXN51_RS10650 (LXN51_10650) 2291083..2291985 + 903 WP_085702733.1 Hsp33 family molecular chaperone HslO -
LXN51_RS10655 (LXN51_10655) 2292167..2293708 + 1542 WP_085702732.1 phosphoenolpyruvate carboxykinase -
LXN51_RS10660 (LXN51_10660) 2293774..2294061 - 288 WP_234206267.1 NadS family protein Antitoxin
LXN51_RS10665 (LXN51_10665) 2294064..2294378 - 315 WP_011331970.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXN51_RS10670 (LXN51_10670) 2294490..2294789 - 300 WP_227234123.1 hypothetical protein -
LXN51_RS10675 (LXN51_10675) 2295133..2296260 - 1128 WP_234206269.1 hypothetical protein -
LXN51_RS10680 (LXN51_10680) 2296363..2296644 - 282 WP_234206271.1 hypothetical protein -
LXN51_RS10685 (LXN51_10685) 2296949..2297452 + 504 WP_234206273.1 polysaccharide deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.76 Da        Isoelectric Point: 10.3534

>T230481 WP_011331970.1 NZ_CP090355:c2294378-2294064 [Pseudomonas kribbensis]
MIFIETRIFTRRVKELLDDDTYAAFQKQLVVSPSIGDVIEGTGGIRKTRIAAKGHGKRGGARVIYYHFVSASQIGLLMIY
PKNEQHDLSSDERKALKVLIEKWR

Download         Length: 315 bp

>T230481 NZ_CP124908:c2619812-2619711 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10716.30 Da        Isoelectric Point: 7.4052

>AT230481 WP_234206267.1 NZ_CP090355:c2294061-2293774 [Pseudomonas kribbensis]
MSKFFDELMESVQEMDEIVRGQRAPSREFHVDALQVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAH

Download         Length: 288 bp

>AT230481 NZ_CP124908:2619589-2619766 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q3KJP2

Antitoxin

Source ID Structure

References