Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1097849..1098429 Replicon chromosome
Accession NZ_CP090355
Organism Pseudomonas kribbensis strain H38E-23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LXN51_RS05185 Protein ID WP_085697557.1
Coordinates 1097849..1098127 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXN51_RS05190 Protein ID WP_045121630.1
Coordinates 1098142..1098429 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN51_RS05165 (LXN51_05165) 1093440..1093607 - 168 WP_007950992.1 DUF2474 domain-containing protein -
LXN51_RS05170 (LXN51_05170) 1093666..1094673 - 1008 WP_085697554.1 cytochrome d ubiquinol oxidase subunit II -
LXN51_RS05175 (LXN51_05175) 1094677..1096113 - 1437 WP_085697555.1 cytochrome ubiquinol oxidase subunit I -
LXN51_RS05180 (LXN51_05180) 1096503..1097741 + 1239 WP_085697556.1 MFS transporter -
LXN51_RS05185 (LXN51_05185) 1097849..1098127 + 279 WP_085697557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXN51_RS05190 (LXN51_05190) 1098142..1098429 + 288 WP_045121630.1 HigA family addiction module antitoxin Antitoxin
LXN51_RS05195 (LXN51_05195) 1098435..1098986 - 552 WP_227233597.1 DJ-1/PfpI family protein -
LXN51_RS05200 (LXN51_05200) 1099054..1099503 - 450 WP_085732881.1 DUF4879 domain-containing protein -
LXN51_RS05205 (LXN51_05205) 1099724..1101019 + 1296 WP_085697559.1 NCS2 family permease -
LXN51_RS05210 (LXN51_05210) 1101016..1102095 + 1080 WP_227233599.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
LXN51_RS05215 (LXN51_05215) 1102151..1102597 - 447 WP_085697561.1 hypothetical protein -
LXN51_RS05220 (LXN51_05220) 1102594..1103022 - 429 WP_227233601.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10687.24 Da        Isoelectric Point: 8.9401

>T230479 WP_085697557.1 NZ_CP090355:1097849-1098127 [Pseudomonas kribbensis]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLSRMLQFMDRAAVPGDLDLPGWRLHPLKGELCEYWSLSVSGNWRVIFRFAG
SDIELVDYLDYH

Download         Length: 279 bp

>T230479 NZ_CP124908:569500-569616 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGTTGGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10542.17 Da        Isoelectric Point: 6.9219

>AT230479 WP_045121630.1 NZ_CP090355:1098142-1098429 [Pseudomonas kribbensis]
MPMHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EHREQPAIQPIAAHA

Download         Length: 288 bp

>AT230479 NZ_CP124908:c569732-569527 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References