Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5352610..5353205 Replicon chromosome
Accession NZ_CP090348
Organism Pseudomonas aeruginosa strain PA8329

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LXN03_RS24925 Protein ID WP_071534808.1
Coordinates 5352927..5353205 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXN03_RS24920 Protein ID WP_004352673.1
Coordinates 5352610..5352915 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN03_RS24895 (LXN03_24895) 5347630..5348064 - 435 WP_004352681.1 hypothetical protein -
LXN03_RS24900 (LXN03_24900) 5348603..5348914 - 312 WP_180719138.1 DUF5447 family protein -
LXN03_RS24905 (LXN03_24905) 5348980..5349252 - 273 WP_176450372.1 DNA-binding protein -
LXN03_RS24910 (LXN03_24910) 5349364..5349636 + 273 WP_180719132.1 DNA-binding protein -
LXN03_RS24915 (LXN03_24915) 5349695..5352265 + 2571 WP_217953707.1 hypothetical protein -
LXN03_RS24920 (LXN03_24920) 5352610..5352915 - 306 WP_004352673.1 HigA family addiction module antitoxin Antitoxin
LXN03_RS24925 (LXN03_24925) 5352927..5353205 - 279 WP_071534808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXN03_RS24930 (LXN03_24930) 5353258..5353386 - 129 Protein_4931 integrase -
LXN03_RS24935 (LXN03_24935) 5353534..5355762 + 2229 WP_004352671.1 TonB-dependent receptor -
LXN03_RS24940 (LXN03_24940) 5355832..5356479 - 648 WP_003095021.1 carbonate dehydratase -
LXN03_RS24945 (LXN03_24945) 5356541..5357779 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 8.5576

>T230472 WP_071534808.1 NZ_CP090348:c5353205-5352927 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T230472 NZ_CP124906:c2560446-2560303 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11238.80 Da        Isoelectric Point: 4.7769

>AT230472 WP_004352673.1 NZ_CP090348:c5352915-5352610 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT230472 NZ_CP124906:2560183-2560370 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References