Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 111380..111633 | Replicon | plasmid pKPK3-2 |
| Accession | NZ_CP090345 | ||
| Organism | Klebsiella pneumoniae strain KPK3 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | LXL84_RS28480 | Protein ID | WP_001312851.1 |
| Coordinates | 111380..111529 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 111574..111633 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXL84_RS28445 (106739) | 106739..107154 | - | 416 | Protein_129 | IS1 family transposase | - |
| LXL84_RS28450 (107403) | 107403..107804 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| LXL84_RS28455 (107737) | 107737..107994 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| LXL84_RS28460 (108087) | 108087..108740 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| LXL84_RS28465 (109679) | 109679..110536 | - | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
| LXL84_RS28470 (110555) | 110555..110733 | - | 179 | Protein_134 | protein CopA/IncA | - |
| LXL84_RS28475 (110848) | 110848..111096 | - | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| LXL84_RS28480 (111380) | 111380..111529 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (111574) | 111574..111633 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (111574) | 111574..111633 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (111574) | 111574..111633 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (111574) | 111574..111633 | + | 60 | NuclAT_1 | - | Antitoxin |
| LXL84_RS28485 (111834) | 111834..112166 | - | 333 | WP_152916585.1 | hypothetical protein | - |
| LXL84_RS28490 (112228) | 112228..112827 | - | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| LXL84_RS28495 (113213) | 113213..113413 | - | 201 | WP_015059022.1 | hypothetical protein | - |
| LXL84_RS28500 (113545) | 113545..114105 | - | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| LXL84_RS28505 (114160) | 114160..114906 | - | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| LXL84_RS28510 (114926) | 114926..115126 | - | 201 | WP_072354025.1 | hypothetical protein | - |
| LXL84_RS28515 (115151) | 115151..115855 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LXL84_RS28520 (115910) | 115910..116002 | - | 93 | Protein_144 | type IV conjugative transfer system protein TraE | - |
| LXL84_RS28525 (116022) | 116022..116327 | - | 306 | WP_004144424.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaKPC-2 / blaSHV-187 / rmtB / blaTEM-1B / blaCTX-M-65 | - | 1..132507 | 132507 | |
| - | flank | IS/Tn | - | - | 115151..115855 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T230464 WP_001312851.1 NZ_CP090345:c111529-111380 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T230464 NZ_CP124905:c1195708-1195364 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA
Antitoxin
Download Length: 60 bp
>AT230464 NZ_CP090345:111574-111633 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
