Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 353923..354569 Replicon chromosome
Accession NZ_CP090343
Organism Klebsiella pneumoniae strain KPK3

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag LXL84_RS01630 Protein ID WP_002920560.1
Coordinates 353923..354270 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LXL84_RS01635 Protein ID WP_002920557.1
Coordinates 354270..354569 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXL84_RS01620 (LXL84_01620) 349849..351282 + 1434 WP_002920564.1 glycogen synthase GlgA -
LXL84_RS01625 (LXL84_01625) 351300..353747 + 2448 WP_002920561.1 glycogen phosphorylase -
LXL84_RS01630 (LXL84_01630) 353923..354270 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXL84_RS01635 (LXL84_01635) 354270..354569 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LXL84_RS01640 (LXL84_01640) 354632..356140 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LXL84_RS01645 (LXL84_01645) 356345..356674 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LXL84_RS01650 (LXL84_01650) 356725..357555 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LXL84_RS01655 (LXL84_01655) 357605..358363 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T230439 WP_002920560.1 NZ_CP090343:353923-354270 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T230439 NZ_CP124898:2765407-2765502 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT230439 WP_002920557.1 NZ_CP090343:354270-354569 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT230439 NZ_CP124898:c2765602-2765537 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References