Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1707492..1708185 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LXF06_RS08165 Protein ID WP_000415584.1
Coordinates 1707492..1707788 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LXF06_RS08170 Protein ID WP_000650107.1
Coordinates 1707790..1708185 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS08130 (1702580) 1702580..1702894 - 315 WP_000958598.1 putative quinol monooxygenase -
LXF06_RS08135 (1702925) 1702925..1703506 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LXF06_RS08140 (1703825) 1703825..1704157 + 333 WP_000917684.1 DUF2645 family protein -
LXF06_RS08145 (1704203) 1704203..1705552 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LXF06_RS08150 (1705549) 1705549..1706208 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LXF06_RS08155 (1706360) 1706360..1706752 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LXF06_RS08160 (1706805) 1706805..1707287 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LXF06_RS08165 (1707492) 1707492..1707788 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LXF06_RS08170 (1707790) 1707790..1708185 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LXF06_RS08175 (1708318) 1708318..1709925 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LXF06_RS08180 (1710063) 1710063..1712321 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T230400 WP_000415584.1 NZ_CP090305:1707492-1707788 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T230400 NZ_CP124889:1622984-1623292 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT230400 WP_000650107.1 NZ_CP090305:1707790-1708185 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT230400 NZ_CP124889:1622710-1622982 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References