Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1641851..1642578 Replicon chromosome
Accession NZ_CP090305
Organism Escherichia coli strain Z503

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag LXF06_RS07855 Protein ID WP_000550189.1
Coordinates 1641851..1642165 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXF06_RS07860 Protein ID WP_000560255.1
Coordinates 1642162..1642578 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF06_RS07835 (1638009) 1638009..1638995 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
LXF06_RS07840 (1639074) 1639074..1639766 - 693 WP_001753077.1 vancomycin high temperature exclusion protein -
LXF06_RS07845 (1639843) 1639843..1640346 - 504 WP_001300832.1 M48 family metallopeptidase -
LXF06_RS07850 (1640431) 1640431..1641567 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
LXF06_RS07855 (1641851) 1641851..1642165 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
LXF06_RS07860 (1642162) 1642162..1642578 + 417 WP_000560255.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
LXF06_RS07865 (1642623) 1642623..1644641 - 2019 WP_088474806.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
LXF06_RS07870 (1645067) 1645067..1647418 - 2352 WP_241415751.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T230399 WP_000550189.1 NZ_CP090305:1641851-1642165 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T230399 NZ_CP124889:c1179838-1179494 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACTTACGGTATCATATTTGTAAATCAAAATTTAACACCAACAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAGAAGACCATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAC
GGGACAAGAAATTTATTTGAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14951.41 Da        Isoelectric Point: 4.5577

>AT230399 WP_000560255.1 NZ_CP090305:1642162-1642578 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT230399 NZ_CP124889:c1180192-1179857 [Enterococcus faecalis]
ATGACAGTGTTTGATAGGATCAAATTATTAGCAAAAGAGAGAGGAAAATCCTTAAATCGAATCGAAGAAGAATTAGGTTT
ACCAAAAAATGTTCTGTATCGTATGAAAACTTCCGATAATCCTACTAAAGATAGACTAGAAACTTTAGCTAATTACTTTG
ATGTATCTGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAAATCTGATGATTTAGATGAT
GTACTGGATAACGTCATGAGCTTTGACGGTAAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGG
TAGATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References