230393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4562576..4563357 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LPC12_RS22115 Protein ID WP_000626099.1
Coordinates 4562866..4563357 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LPC12_RS22110 Protein ID WP_001110452.1
Coordinates 4562576..4562869 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS22075 (4558188) 4558188..4559093 + 906 WP_001268200.1 YjiK family protein -
LPC12_RS22080 (4559432) 4559432..4559890 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
LPC12_RS22085 (4560099) 4560099..4560368 - 270 WP_010989096.1 hypothetical protein -
LPC12_RS22090 (4560376) 4560376..4560591 - 216 WP_001595136.1 hypothetical protein -
LPC12_RS22095 (4560614) 4560614..4560901 - 288 WP_001269916.1 transcriptional regulator RtsB -
LPC12_RS22100 (4560898) 4560898..4561773 - 876 WP_000921675.1 AraC family transcriptional regulator -
LPC12_RS22105 (4562038) 4562038..4562259 - 222 WP_001576552.1 hypothetical protein -
LPC12_RS22110 (4562576) 4562576..4562869 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LPC12_RS22115 (4562866) 4562866..4563357 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LPC12_RS22120 (4563605) 4563605..4564357 - 753 WP_000842434.1 non-specific acid phosphatase -
LPC12_RS22125 (4564460) 4564460..4564534 - 75 Protein_4315 porin family protein -
LPC12_RS22130 (4565566) 4565566..4565943 - 378 WP_000916345.1 EthD family reductase -
LPC12_RS22135 (4566015) 4566015..4566347 + 333 WP_001165471.1 MerR family transcriptional regulator -
LPC12_RS22140 (4566438) 4566438..4566515 + 78 Protein_4318 helix-turn-helix domain-containing protein -
LPC12_RS22150 (4566786) 4566786..4567361 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4559432..4559890 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T230393 WP_000626099.1 NZ_CP090304:4562866-4563357 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T230393 NZ_CP124889:c275612-275469 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT230393 WP_001110452.1 NZ_CP090304:4562576-4562869 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT230393 NZ_CP124889:275710-275908 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References