230392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4241649..4242251 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag LPC12_RS20690 Protein ID WP_001159630.1
Coordinates 4241649..4241960 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPC12_RS20695 Protein ID WP_000362050.1
Coordinates 4241961..4242251 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS20655 (4236762) 4236762..4237361 + 600 WP_000965695.1 glucose-1-phosphatase -
LPC12_RS20660 (4237355) 4237355..4238227 + 873 WP_000921427.1 virulence factor BrkB family protein -
LPC12_RS20665 (4238224) 4238224..4238661 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LPC12_RS20670 (4238706) 4238706..4239647 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LPC12_RS20675 (4239662) 4239662..4240108 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
LPC12_RS20680 (4240105) 4240105..4240416 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
LPC12_RS20685 (4240502) 4240502..4241431 - 930 WP_001127703.1 alpha/beta hydrolase -
LPC12_RS20690 (4241649) 4241649..4241960 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LPC12_RS20695 (4241961) 4241961..4242251 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LPC12_RS20700 (4242298) 4242298..4243227 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LPC12_RS20705 (4243224) 4243224..4243859 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LPC12_RS20710 (4243856) 4243856..4244758 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T230392 WP_001159630.1 NZ_CP090304:4241649-4241960 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T230392 NZ_CP124889:c275612-275469 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT230392 WP_000362050.1 NZ_CP090304:4241961-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT230392 NZ_CP124889:c275325-275276 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References