Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4239662..4240416 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LPC12_RS20680 Protein ID WP_000558166.1
Coordinates 4240105..4240416 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPC12_RS20675 Protein ID WP_001259011.1
Coordinates 4239662..4240108 (-) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS20645 (4234838) 4234838..4235734 + 897 WP_001520529.1 sugar kinase -
LPC12_RS20650 (4235768) 4235768..4236571 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LPC12_RS20655 (4236762) 4236762..4237361 + 600 WP_000965695.1 glucose-1-phosphatase -
LPC12_RS20660 (4237355) 4237355..4238227 + 873 WP_000921427.1 virulence factor BrkB family protein -
LPC12_RS20665 (4238224) 4238224..4238661 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LPC12_RS20670 (4238706) 4238706..4239647 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LPC12_RS20675 (4239662) 4239662..4240108 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LPC12_RS20680 (4240105) 4240105..4240416 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LPC12_RS20685 (4240502) 4240502..4241431 - 930 WP_001127703.1 alpha/beta hydrolase -
LPC12_RS20690 (4241649) 4241649..4241960 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LPC12_RS20695 (4241961) 4241961..4242251 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
LPC12_RS20700 (4242298) 4242298..4243227 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LPC12_RS20705 (4243224) 4243224..4243859 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LPC12_RS20710 (4243856) 4243856..4244758 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T230391 WP_000558166.1 NZ_CP090304:c4240416-4240105 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T230391 NZ_CP124888:29155-29496 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT230391 WP_001259011.1 NZ_CP090304:c4240108-4239662 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT230391 NZ_CP124888:28925-29155 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References