Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4505372..4506000 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag LXH15_RS21625 Protein ID WP_016930174.1
Coordinates 4505372..4505662 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXH15_RS21630 Protein ID WP_016930175.1
Coordinates 4505677..4506000 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS21615 (LXH15_21615) 4501946..4503967 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
LXH15_RS21620 (LXH15_21620) 4504002..4505141 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
LXH15_RS21625 (LXH15_21625) 4505372..4505662 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXH15_RS21630 (LXH15_21630) 4505677..4506000 + 324 WP_016930175.1 HigA family addiction module antitoxin Antitoxin
LXH15_RS21635 (LXH15_21635) 4505993..4506505 + 513 WP_016930176.1 M48 family metallopeptidase -
LXH15_RS21640 (LXH15_21640) 4506555..4507535 + 981 WP_234213203.1 Gfo/Idh/MocA family oxidoreductase -
LXH15_RS21645 (LXH15_21645) 4507537..4508268 + 732 WP_234213204.1 glutamine amidotransferase -
LXH15_RS21650 (LXH15_21650) 4508524..4509489 + 966 WP_028127587.1 TerC family protein -
LXH15_RS21655 (LXH15_21655) 4509753..4510988 + 1236 WP_234213205.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T230357 WP_016930174.1 NZ_CP090244:4505372-4505662 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T230357 NZ_CP124883:11689-11964 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAACAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAACTATTTCGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT230357 WP_016930175.1 NZ_CP090244:4505677-4506000 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT230357 NZ_CP124883:11430-11696 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References