Detailed information of TA system TA023034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 2125058..2125697
• Replicon: chromosome
• Accession: NC_011146
• Organism: Geobacter bemidjiensis Bem

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GBEM_RS09175
• Protein ID: WP_012530262.1
• Coordinates: 2125058..2125396 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GBEM_RS09180
• Protein ID: WP_012530263.1
• Coordinates: 2125386..2125697 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBEM_RS09170	2122707..2124971	+	2265	WP_012530261.1	alpha-amylase	-
GBEM_RS09175	2125058..2125396	+	339	WP_012530262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GBEM_RS09180	2125386..2125697	+	312	WP_012530263.1	helix-turn-helix domain-containing protein	Antitoxin
GBEM_RS09185	2125838..2127346	-	1509	WP_012530264.1	hypothetical protein	-
GBEM_RS09190	2127346..2128260	-	915	WP_012530265.1	type II secretion system F family protein	-
GBEM_RS09195	2128272..2129222	-	951	WP_012530266.1	type II secretion system F family protein	-
GBEM_RS09200	2129225..2130538	-	1314	WP_012530267.1	CpaF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-96)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12801.01 Da
• Isoelectric Point: 8.9539

>T23034 WP_012530262.1 NC_011146:2125058-2125396 [Geobacter bemidjiensis Bem]
MVMVFRLSYYDEAVEVELDAWPVGLRAPFRALTIRMEEYGPNLGMPHTRALGNGLFEIRAKAEEGIGRAFFCTMVGRKII
ILHSFIKKTDKTPKRELDIALARQKEVFGNEL

Nucleotide

• Length: 339 bp

>T23034 NC_011146:2125058-2125396 [Geobacter bemidjiensis Bem]
ATGGTCATGGTTTTCCGACTTTCATATTATGATGAAGCTGTCGAGGTTGAACTTGATGCTTGGCCAGTGGGGCTACGCGC
ACCTTTCCGGGCGTTGACCATACGTATGGAAGAATATGGGCCAAATTTGGGCATGCCGCATACTCGGGCATTAGGAAACG
GCCTCTTTGAAATACGCGCCAAAGCAGAAGAAGGAATCGGTAGAGCCTTTTTCTGCACCATGGTGGGGAGAAAGATCATA
ATTCTCCATAGCTTCATCAAAAAGACGGACAAGACACCAAAACGGGAACTAGACATAGCGCTTGCCCGTCAGAAGGAGGT
ATTTGGTAATGAGCTATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11630.48 Da
• Isoelectric Point: 8.5012

>AT23034 WP_012530263.1 NC_011146:2125386-2125697 [Geobacter bemidjiensis Bem]
MSYKPISYHPKKKLEQELQDPTFKQEWEALEDEFAALDVLLKARKAAGLTQEQVAAKMGVSQPSLARVEASLCSHRHSPS
LEMLRKYAAAVNCKLEIKLVPQH

Nucleotide

• Length: 312 bp

>AT23034 NC_011146:2125386-2125697 [Geobacter bemidjiensis Bem]
ATGAGCTATAAACCGATTTCGTATCATCCCAAGAAAAAGCTGGAGCAAGAGCTTCAAGATCCGACTTTTAAGCAGGAATG
GGAAGCCTTGGAAGATGAATTTGCCGCGTTGGATGTCCTGCTTAAAGCACGTAAAGCAGCGGGGCTTACCCAGGAACAGG
TTGCCGCCAAGATGGGTGTGTCACAGCCATCGTTGGCAAGGGTTGAAGCGTCGCTTTGTTCTCACCGGCATTCTCCATCT
CTGGAAATGCTTCGCAAATATGCTGCGGCTGTTAATTGTAAACTTGAGATAAAGCTGGTGCCGCAGCACTGA