Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 765921..766614 Replicon chromosome
Accession NZ_CP090212
Organism Escherichia coli strain BY68

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LVJ26_RS03705 Protein ID WP_000415584.1
Coordinates 765921..766217 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LVJ26_RS03710 Protein ID WP_000650107.1
Coordinates 766219..766614 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ26_RS03670 (761009) 761009..761323 - 315 WP_000958598.1 putative quinol monooxygenase -
LVJ26_RS03675 (761354) 761354..761935 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LVJ26_RS03680 (762254) 762254..762586 + 333 WP_000917684.1 DUF2645 family protein -
LVJ26_RS03685 (762632) 762632..763981 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LVJ26_RS03690 (763978) 763978..764637 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LVJ26_RS03695 (764789) 764789..765181 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LVJ26_RS03700 (765234) 765234..765716 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LVJ26_RS03705 (765921) 765921..766217 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LVJ26_RS03710 (766219) 766219..766614 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LVJ26_RS03715 (766747) 766747..768354 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LVJ26_RS03720 (768492) 768492..770750 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T230255 WP_000415584.1 NZ_CP090212:765921-766217 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T230255 NZ_CP124819:c597774-597667 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTAGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGACTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT230255 WP_000650107.1 NZ_CP090212:766219-766614 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT230255 NZ_CP124819:597821-597887 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References