Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 532080..532804 Replicon plasmid unnamed1
Accession NZ_CP090208
Organism Pantoea agglomerans strain HJS002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZU96_RS22320 Protein ID WP_233988769.1
Coordinates 532496..532804 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZU96_RS22315 Protein ID WP_233988768.1
Coordinates 532080..532499 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU96_RS22295 (LZU96_22295) 527091..528032 - 942 WP_233988764.1 ABC transporter substrate-binding protein -
LZU96_RS22300 (LZU96_22300) 528044..529357 - 1314 WP_233988765.1 LLM class flavin-dependent oxidoreductase -
LZU96_RS22305 (LZU96_22305) 529440..530594 - 1155 WP_233988766.1 amidohydrolase -
LZU96_RS22310 (LZU96_22310) 530617..531618 - 1002 WP_233988767.1 MsnO8 family LLM class oxidoreductase -
LZU96_RS22315 (LZU96_22315) 532080..532499 - 420 WP_233988768.1 transcriptional regulator Antitoxin
LZU96_RS22320 (LZU96_22320) 532496..532804 - 309 WP_233988769.1 type II toxin-antitoxin system HigB family toxin Toxin
LZU96_RS22325 (LZU96_22325) 533255..534808 + 1554 WP_233988770.1 aspartate aminotransferase family protein -
LZU96_RS22330 (LZU96_22330) 534819..536111 + 1293 WP_233988771.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..548340 548340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(19-92)

Antitoxin

Antitoxin HigA

(2-136)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12319.25 Da        Isoelectric Point: 9.9666

>T230252 WP_233988769.1 NZ_CP090208:c532804-532496 [Pantoea agglomerans]
MHVISREPFREAAEFPNDATALDAIYLVLKGENFRSPDALKKRFPSLDRMKYREKWWVIDAGGNNLRIMFFVDFERSKIF
IKHIVTHPEYDRLIKKYREQKE

Download         Length: 309 bp

>T230252 NZ_CP124819:110555-110809 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15760.97 Da        Isoelectric Point: 5.2508

>AT230252 WP_233988768.1 NZ_CP090208:c532499-532080 [Pantoea agglomerans]
MITEAIQATNQLIEIIPFLGGSTQKKDYEQALELVEYLVEHQPDSPLIDMLADKVARYEDNAPEFAEFNARIAKMPQGVA
LLRVLMDQYGLNQSSFTEEIGQRSYVSRILRGQRSLTDKHKARLAARFNLPFEAFNGKA

Download         Length: 420 bp

>AT230252 NZ_CP124819:110307-110558 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References