Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1648104..1648764 Replicon chromosome
Accession NZ_CP090207
Organism Pantoea agglomerans strain HJS002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZU96_RS07695 Protein ID WP_233987741.1
Coordinates 1648104..1648457 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZU96_RS07700 Protein ID WP_233987742.1
Coordinates 1648462..1648764 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZU96_RS07670 (LZU96_07670) 1643651..1644361 + 711 WP_233987737.1 carboxymuconolactone decarboxylase family protein -
LZU96_RS07675 (LZU96_07675) 1644371..1644628 + 258 WP_233987738.1 YfhL family 4Fe-4S dicluster ferredoxin -
LZU96_RS07685 (LZU96_07685) 1645322..1646386 + 1065 WP_233987739.1 class I mannose-6-phosphate isomerase -
LZU96_RS07690 (LZU96_07690) 1646714..1647805 + 1092 WP_233987740.1 YncE family protein -
LZU96_RS07695 (LZU96_07695) 1648104..1648457 + 354 WP_233987741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZU96_RS07700 (LZU96_07700) 1648462..1648764 + 303 WP_233987742.1 XRE family transcriptional regulator Antitoxin
LZU96_RS07710 (LZU96_07710) 1649430..1650353 + 924 WP_233987743.1 sugar ABC transporter substrate-binding protein -
LZU96_RS07715 (LZU96_07715) 1650386..1651870 + 1485 WP_233987744.1 sugar ABC transporter ATP-binding protein -
LZU96_RS07720 (LZU96_07720) 1651894..1652919 + 1026 WP_233988156.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1631198..1654844 23646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13548.61 Da        Isoelectric Point: 8.4949

>T230246 WP_233987741.1 NZ_CP090207:1648104-1648457 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAGLMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGEPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYREMLPVADGEFTHWLNGFKDEE

Download         Length: 354 bp

>T230246 NZ_CP124813:c4050010-4049687 [Citrobacter freundii]
ATGAAAATTCTACCGGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCACCCGTTGCAGTCTGGCAATTGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATTTCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGAATATTGATATCATGAGGGCCCGCCGCGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10925.72 Da        Isoelectric Point: 5.7251

>AT230246 WP_233987742.1 NZ_CP090207:1648462-1648764 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHFGFEV

Download         Length: 303 bp

>AT230246 NZ_CP124813:c4050348-4050031 [Citrobacter freundii]
ATGAGCAACATCATTTGGGGCCTGCAGCGCGATATCACGCCGCGCCTGGGAACACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTACCTGGCTGACCGGGCCTGTATCACAGGTAAGTTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCGGATGGAATCCATGCTGAGCACGGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGTGGCTATGTATACGTCGCTGTTTATTCCAGTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References