Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 74384..74802 Replicon plasmid p1
Accession NZ_CP090197
Organism Escherichia coli strain YL3

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag LXN07_RS24935 Protein ID WP_223412041.1
Coordinates 74680..74802 (+) Length 41 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 74384..74588 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXN07_RS24895 69609..69782 - 174 Protein_83 hypothetical protein -
LXN07_RS24900 70084..70605 + 522 WP_012881138.1 single-stranded DNA-binding protein -
LXN07_RS24905 70661..70894 + 234 WP_000005971.1 DUF905 domain-containing protein -
LXN07_RS24910 70958..72916 + 1959 WP_257120052.1 ParB/RepB/Spo0J family partition protein -
LXN07_RS24915 72971..73405 + 435 WP_000845949.1 conjugation system SOS inhibitor PsiB -
LXN07_RS24920 73402..74121 + 720 WP_012881136.1 plasmid SOS inhibition protein A -
LXN07_RS24925 74118..74432 + 315 WP_000872086.1 hypothetical protein -
- 74381..74588 + 208 NuclAT_0 - -
- 74381..74588 + 208 NuclAT_0 - -
- 74381..74588 + 208 NuclAT_0 - -
- 74381..74588 + 208 NuclAT_0 - -
- 74384..74588 - 205 - - Antitoxin
LXN07_RS24930 74622..74735 + 114 Protein_90 DUF5431 family protein -
LXN07_RS24935 74680..74802 + 123 WP_223412041.1 Hok/Gef family protein Toxin
LXN07_RS24940 75103..75352 - 250 Protein_92 hypothetical protein -
LXN07_RS24945 75648..75971 + 324 WP_000533253.1 hypothetical protein -
LXN07_RS24950 76030..76272 + 243 WP_000540588.1 hypothetical protein -
LXN07_RS24955 76472..76624 - 153 Protein_95 hypothetical protein -
LXN07_RS24960 76737..78404 - 1668 WP_117313998.1 group II intron reverse transcriptase/maturase -
LXN07_RS24965 79133..79306 - 174 Protein_97 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..97598 97598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 41 a.a.        Molecular weight: 4560.33 Da        Isoelectric Point: 8.2774

>T230214 WP_223412041.1 NZ_CP090197:74680-74802 [Escherichia coli]
IVCCTLLIFTHLTRNRLCEVRLKDGYREVTASLAYESSGK

Download         Length: 123 bp

>T230214 NZ_CP124804:197143-197628 [Klebsiella variicola]
GTGGGAAGTTTAACAGCACCAGAACCTTTATCCAGCTTTCATCAGGTGGCAGAGTTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACGTTTGTAGTGTGTAAGAAAGACACAA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATCATACTTGCCCGTCTTGCAGTCGATCTCTCTTTTCGCGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATTATGGTTCACGCACTCACCG
AAGAAGCTAACAATTTCTACATTCACCATGGTTTCAAGCCATCACAAACTCAGCAACGGACATTATTCCTTAAACTGCCT
CAATAA

Antitoxin


Download         Length: 205 bp

>AT230214 NZ_CP090197:c74588-74384 [Escherichia coli]
AGACATACAGGGGGCCTCGTGGGTTAATGAAAAATTAACTACGGGGCTTTCTGCCTTCTGCCACACAACACGGTAACAAA
CCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCGCACTGACCACACTCAC
TTTCCCTGAAAATAATCCGGTCGTTCAGCCAGTTCACGGGCAATC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References