Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 4022212..4022906 | Replicon | chromosome |
| Accession | NZ_CP090196 | ||
| Organism | Escherichia coli strain YL3 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | A0A0D8WHS4 |
| Locus tag | LXN07_RS19340 | Protein ID | WP_001521903.1 |
| Coordinates | 4022212..4022610 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1QAE3 |
| Locus tag | LXN07_RS19345 | Protein ID | WP_000554758.1 |
| Coordinates | 4022613..4022906 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (4018042) | 4018042..4018122 | - | 81 | NuclAT_11 | - | - |
| - (4018042) | 4018042..4018122 | - | 81 | NuclAT_11 | - | - |
| - (4018042) | 4018042..4018122 | - | 81 | NuclAT_11 | - | - |
| - (4018042) | 4018042..4018122 | - | 81 | NuclAT_11 | - | - |
| LXN07_RS19310 (4017382) | 4017382..4018626 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| LXN07_RS19315 (4018718) | 4018718..4019176 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| LXN07_RS19320 (4019437) | 4019437..4020894 | + | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
| LXN07_RS19325 (4020951) | 4020951..4021303 | - | 353 | Protein_3785 | peptide chain release factor H | - |
| LXN07_RS19330 (4021299) | 4021299..4021505 | - | 207 | Protein_3786 | RtcB family protein | - |
| LXN07_RS19335 (4021750) | 4021750..4022202 | - | 453 | WP_023144376.1 | GNAT family N-acetyltransferase | - |
| LXN07_RS19340 (4022212) | 4022212..4022610 | - | 399 | WP_001521903.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| LXN07_RS19345 (4022613) | 4022613..4022906 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| LXN07_RS19350 (4022958) | 4022958..4024013 | - | 1056 | WP_001226177.1 | DNA polymerase IV | - |
| LXN07_RS19355 (4024084) | 4024084..4024869 | - | 786 | WP_000207556.1 | putative lateral flagellar export/assembly protein LafU | - |
| LXN07_RS19360 (4024841) | 4024841..4026553 | + | 1713 | Protein_3792 | flagellar biosynthesis protein FlhA | - |
| LXN07_RS19365 (4026632) | 4026632..4026985 | + | 354 | WP_024166466.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LXN07_RS19370 (4027042) | 4027042..4027791 | - | 750 | WP_016233951.1 | C40 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4012149..4022906 | 10757 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15471.88 Da Isoelectric Point: 8.0949
>T230205 WP_001521903.1 NZ_CP090196:c4022610-4022212 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGILPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T230205 NZ_CP124754:c3105219-3104821 [Serratia sp. K-E0102]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGTTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATACTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGTTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATACTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT230205 WP_000554758.1 NZ_CP090196:c4022906-4022613 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT230205 NZ_CP124754:c3105452-3105219 [Serratia sp. K-E0102]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D8WHS4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1QAE3 |