Detailed information of TA system TA230181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4766892..4767494
• Replicon: chromosome
• Accession: NZ_CP090192
• Organism: Enterobacter hormaechei strain TUECL19003

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A155DUZ6
• Locus tag: LZU72_RS22795
• Protein ID: WP_022649837.1
• Coordinates: 4767183..4767494 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LZU72_RS22790
• Protein ID: WP_022649836.1
• Coordinates: 4766892..4767182 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZU72_RS22775 (LZU72_22775)	4764390..4765292	+	903	WP_003861960.1	formate dehydrogenase subunit beta	-
LZU72_RS22780 (LZU72_22780)	4765289..4765924	+	636	WP_006808711.1	formate dehydrogenase cytochrome b556 subunit	-
LZU72_RS22785 (LZU72_22785)	4765921..4766850	+	930	WP_022649835.1	formate dehydrogenase accessory protein FdhE	-
LZU72_RS22790 (LZU72_22790)	4766892..4767182	-	291	WP_022649836.1	NadS family protein	Antitoxin
LZU72_RS22795 (LZU72_22795)	4767183..4767494	-	312	WP_022649837.1	hypothetical protein	Toxin
LZU72_RS22800 (LZU72_22800)	4767643..4768584	-	942	WP_022649838.1	fatty acid biosynthesis protein FabY	-
LZU72_RS22805 (LZU72_22805)	4768629..4769066	-	438	WP_022649839.1	D-aminoacyl-tRNA deacylase	-
LZU72_RS22810 (LZU72_22810)	4769063..4769944	-	882	WP_022649840.1	virulence factor BrkB family protein	-
LZU72_RS22815 (LZU72_22815)	4769938..4770537	-	600	WP_022649841.1	glucose-1-phosphatase	-
LZU72_RS22820 (LZU72_22820)	4770656..4771456	-	801	WP_022649842.1	DeoR/GlpR family DNA-binding transcription regulator	-
LZU72_RS22825 (LZU72_22825)	4771491..4772387	-	897	WP_022649843.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12148.13 Da
• Isoelectric Point: 9.4455

>T230181 WP_022649837.1 NZ_CP090192:c4767494-4767183 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Nucleotide

• Length: 312 bp

>T230181 NZ_CP124744:c2226511-2225438 [Proteus mirabilis]
ATGACAGTCAGAAGTTATCAGGATTTAAATCTGGACAGGGCTAACATCGAAACTGAATGTAGGCAGTTCATTCAAACTAG
AGCGTATACAGTTCAGTCAATTGGCCCAATGCCGGGGCAAAGACCCGGACTCCGAGTGACATTCGCGAAAATAGGGGAAA
ATTTCGCAACCGTTAATATTTTCTACAACGGCAATGGCTCATGTACAGTTCAGTATCTTACGGGGGCTAATCGGCCTCTA
GGCAAGGAGCTTGCTGATTACCTTTTTGAAACAATTAATCCTGCAGAATTTGAACATGTAAATATGGTCTTAGAAGGATT
CGTGGAGAACACAATTTTACCTGTGCTTGAATTATCAGCAGAAGAAACACATATTGAGTTCAGGGAACACCTTCGTAACC
ATCACTCCATCATGTGGAAAATCACCTCTACTACCAACCAGGATGAATTGACAGTTACCTTGCACACCACAACAGGCAAG
CTTCAGATTCAGGGCCGTCCACTATCCTGCTATCGGGTTTTCATTTTCAACATAGCAGAATTGCTTAATTTGCAAGGTCT
GGAGAAAGTGTTAATCCGCCAAGATGATGGTAAAGCAAACATCGTTCAACAGGAAGTAGCCCGTGCTAATCTGGAGTCTA
TAATGGGTGATGCTTATCCTTGCTTGCACGCAGCCGCTGAAAAATTGCTCATTTCAGGTCTGTGTGTTAAGCTAGCCGCC
CCTAAATTACCAGACTACTGCATGTTGCTCTACCCGGAACTTCGCTCCATTGAGGGTGTCTTAAAGAATAAGATGTACGC
ATTTGGCATGTCTGTACAGCAACCTTTAGGATTCGGGCCTTTTTTCGATAAAGTTGGTTTAAATTACACCTTGAAACTAC
AATATGCGAATACTCTCAGGCCTGAACAGGTTAATATCATCAATGATGCTTATACGTTCTGGAATCAGGAACGTCATGCT
GTGTTTCACATGGAAACAGTAGTTGATACCAGTCGCATGATTTCCGATATGGCTCGACTAATGACTAAAGCCACTAAAGC
GTGGCAAATAATCAAGGATTTGTATATTGTTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10699.21 Da
• Isoelectric Point: 10.5888

>AT230181 WP_022649836.1 NZ_CP090192:c4767182-4766892 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Nucleotide

• Length: 291 bp

>AT230181 NZ_CP124744:c2225445-2225074 [Proteus mirabilis]
TTGTTTGAAATTACCAGAGTTAACGTCTCAGGATCTCTTAAAGCTGTCGTTATGGCAACCAGCTACGAGAACCCGTTGTC
TTCAGTCAACGAAATTGAGATGAAACTCACTGGCCTACTGGGCGAGTGTGAAAATGGTAAAATTCTTTTCGATCTCCTAT
GCTCTAACGGCCCCGAGTGGAACCGATTTGTGACCCTTGAAATAAGATTAGGCCGCATCATGCTAGATTCGGCCCAAATT
ATTGATCAGAAGGAAATACCGGCACAGATTCTGAGTAAACTAACCTTTATTTTACAGAATCATCCTGAGTACCTAGAAGC
ATCCGTATTGACCCCTGATGACGTACGCCAAGTACTTTCAATGGATATGTGA

Structures

Toxin

• AlphaFold DB: A0A155DUZ6