Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 569234..569867 Replicon chromosome
Accession NZ_CP090179
Organism Vibrio harveyi strain XH2145

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LXG94_RS12845 Protein ID WP_038883034.1
Coordinates 569234..569566 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXG94_RS12850 Protein ID WP_038899623.1
Coordinates 569553..569867 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXG94_RS12790 (LXG94_12790) 564501..564593 + 93 WP_072600976.1 DUF3265 domain-containing protein -
LXG94_RS12795 (LXG94_12795) 564628..565071 + 444 WP_012127694.1 hypothetical protein -
LXG94_RS12800 (LXG94_12800) 565086..565178 + 93 WP_193788550.1 DUF3265 domain-containing protein -
LXG94_RS12805 (LXG94_12805) 565214..566422 + 1209 WP_038899620.1 serine/threonine-protein kinase -
LXG94_RS12810 (LXG94_12810) 566452..566544 + 93 WP_017420683.1 DUF3265 domain-containing protein -
LXG94_RS12815 (LXG94_12815) 566708..566944 - 237 WP_162211059.1 hypothetical protein -
LXG94_RS12820 (LXG94_12820) 567073..567162 + 90 WP_079883834.1 DUF3265 domain-containing protein -
LXG94_RS12825 (LXG94_12825) 567262..567564 - 303 WP_102949587.1 hypothetical protein -
LXG94_RS12830 (LXG94_12830) 567690..567782 + 93 WP_193278984.1 DUF3265 domain-containing protein -
LXG94_RS12835 (LXG94_12835) 568254..568319 + 66 Protein_601 DUF3265 domain-containing protein -
LXG94_RS12840 (LXG94_12840) 568410..568919 - 510 WP_038899622.1 MerR family transcriptional regulator -
LXG94_RS12845 (LXG94_12845) 569234..569566 + 333 WP_038883034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXG94_RS12850 (LXG94_12850) 569553..569867 + 315 WP_038899623.1 DNA-binding transcriptional regulator Antitoxin
LXG94_RS12855 (LXG94_12855) 569882..569974 + 93 WP_140317514.1 DUF3265 domain-containing protein -
LXG94_RS12860 (LXG94_12860) 570510..570575 + 66 Protein_606 DUF3265 domain-containing protein -
LXG94_RS12865 (LXG94_12865) 570877..571179 + 303 WP_233921905.1 hypothetical protein -
LXG94_RS12870 (LXG94_12870) 571194..571286 + 93 WP_080640453.1 DUF3265 domain-containing protein -
LXG94_RS12875 (LXG94_12875) 571313..571720 + 408 WP_038899727.1 DUF1330 domain-containing protein -
LXG94_RS12880 (LXG94_12880) 571747..571839 + 93 WP_193788553.1 DUF3265 domain-containing protein -
LXG94_RS12885 (LXG94_12885) 571869..572195 + 327 WP_038899725.1 hypothetical protein -
LXG94_RS12890 (LXG94_12890) 572192..572269 + 78 Protein_612 DUF3265 domain-containing protein -
LXG94_RS12895 (LXG94_12895) 572813..572944 + 132 WP_080990692.1 DUF3265 domain-containing protein -
LXG94_RS12900 (LXG94_12900) 573075..573326 + 252 WP_127891278.1 hypothetical protein -
LXG94_RS12905 (LXG94_12905) 573348..573440 + 93 WP_079400415.1 DUF3265 domain-containing protein -
LXG94_RS12910 (LXG94_12910) 573859..573987 + 129 WP_077200607.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 509766..632527 122761
- inside Integron - - 508515..626933 118418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin

Antitoxin MqsA/HigA-2

(24-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12934.81 Da        Isoelectric Point: 10.0960

>T230159 WP_038883034.1 NZ_CP090179:569234-569566 [Vibrio harveyi]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTVDQKKQLKAFMEAWRNEQS

Download         Length: 333 bp

>T230159 NZ_CP124740:919481-919867 [Escherichia coli O157:H7 str. EDL933]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11703.19 Da        Isoelectric Point: 6.6448

>AT230159 WP_038899623.1 NZ_CP090179:569553-569867 [Vibrio harveyi]
MSNRNLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT230159 NZ_CP124740:919857-920186 [Escherichia coli O157:H7 str. EDL933]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References