Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4454776..4455530 | Replicon | chromosome |
| Accession | NZ_CP090141 | ||
| Organism | Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LZK30_RS21275 | Protein ID | WP_133323219.1 |
| Coordinates | 4454776..4455087 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LZK30_RS21280 | Protein ID | WP_001259009.1 |
| Coordinates | 4455084..4455530 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZK30_RS21245 (4450434) | 4450434..4451336 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| LZK30_RS21250 (4451333) | 4451333..4451968 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LZK30_RS21255 (4451965) | 4451965..4452894 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| LZK30_RS21260 (4452941) | 4452941..4453231 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LZK30_RS21265 (4453232) | 4453232..4453543 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LZK30_RS21270 (4453761) | 4453761..4454690 | + | 930 | WP_001127694.1 | alpha/beta hydrolase | - |
| LZK30_RS21275 (4454776) | 4454776..4455087 | + | 312 | WP_133323219.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LZK30_RS21280 (4455084) | 4455084..4455530 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LZK30_RS21285 (4455545) | 4455545..4456486 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LZK30_RS21290 (4456531) | 4456531..4456968 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| LZK30_RS21295 (4456965) | 4456965..4457837 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LZK30_RS21300 (4457831) | 4457831..4458430 | - | 600 | WP_000965698.1 | glucose-1-phosphatase | - |
| LZK30_RS21305 (4458621) | 4458621..4459424 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LZK30_RS21310 (4459458) | 4459458..4460354 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12490.44 Da Isoelectric Point: 9.1995
>T230136 WP_133323219.1 NZ_CP090141:4454776-4455087 [Salmonella enterica subsp. enterica serovar Goldcoast]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T230136 NZ_CP124732:5047602-5047952 [Pseudomonas sp. GM17]
ATGGACGCGCTTTTTATTGAGTTACCCCCGTTCCAGCGCTATCGACAGGACTATCTGGACGACGAGCTTTTTCGTAGCCT
GCAGCTTGAATTGCTCAAAGCCCCCGAAGCCGGAGATCTCATCGAAGGAACCGGTGGCTTGCGCAAGATCCGTTTTGTCG
ATGAACGAAGACACAAGGGCAAACGCGGCGGAATCAGGGTGATCTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAGCGACCTGGCACCCCAACAGAAAAAACTGCTCAAGCAACTGTTGAACAGAGA
AGTCGAGGCAAGGACCCATCATGAAACGTGA
ATGGACGCGCTTTTTATTGAGTTACCCCCGTTCCAGCGCTATCGACAGGACTATCTGGACGACGAGCTTTTTCGTAGCCT
GCAGCTTGAATTGCTCAAAGCCCCCGAAGCCGGAGATCTCATCGAAGGAACCGGTGGCTTGCGCAAGATCCGTTTTGTCG
ATGAACGAAGACACAAGGGCAAACGCGGCGGAATCAGGGTGATCTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAGCGACCTGGCACCCCAACAGAAAAAACTGCTCAAGCAACTGTTGAACAGAGA
AGTCGAGGCAAGGACCCATCATGAAACGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT230136 WP_001259009.1 NZ_CP090141:4455084-4455530 [Salmonella enterica subsp. enterica serovar Goldcoast]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT230136 NZ_CP124732:5047942-5048256 [Pseudomonas sp. GM17]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACGCCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
TAGCCACAAGGTCAAGCTGAGCGCATTGCTCCCGATCACCGCCGAAGAAGTGCTGGCCGTGCGCGAGCAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAACACTCGAACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCTCAGGCCACCACCCTGATCCGCCTGGTACAGCGCTTTCCCGATACGGTGGAGCGGCTGGCAGCACTGGCCTGA
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACGCCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
TAGCCACAAGGTCAAGCTGAGCGCATTGCTCCCGATCACCGCCGAAGAAGTGCTGGCCGTGCGCGAGCAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAACACTCGAACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCTCAGGCCACCACCCTGATCCGCCTGGTACAGCGCTTTCCCGATACGGTGGAGCGGCTGGCAGCACTGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|