Detailed information of TA system TA230135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4452941..4453543
• Replicon: chromosome
• Accession: NZ_CP090141
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LZK30_RS21265
• Protein ID: WP_001159630.1
• Coordinates: 4453232..4453543 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LZK30_RS21260
• Protein ID: WP_000362050.1
• Coordinates: 4452941..4453231 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK30_RS21245 (4450434)	4450434..4451336	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LZK30_RS21250 (4451333)	4451333..4451968	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LZK30_RS21255 (4451965)	4451965..4452894	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LZK30_RS21260 (4452941)	4452941..4453231	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LZK30_RS21265 (4453232)	4453232..4453543	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LZK30_RS21270 (4453761)	4453761..4454690	+	930	WP_001127694.1	alpha/beta hydrolase	-
LZK30_RS21275 (4454776)	4454776..4455087	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
LZK30_RS21280 (4455084)	4455084..4455530	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LZK30_RS21285 (4455545)	4455545..4456486	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LZK30_RS21290 (4456531)	4456531..4456968	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
LZK30_RS21295 (4456965)	4456965..4457837	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LZK30_RS21300 (4457831)	4457831..4458430	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T230135 WP_001159630.1 NZ_CP090141:c4453543-4453232 [Salmonella enterica subsp. enterica serovar Goldcoast]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T230135 NZ_CP124732:c4820879-4820598 [Pseudomonas sp. GM17]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGCCTCGTCAACCCCCATGTCCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACGGCTGGCTACCGTCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCTGTGGGCAAG
CGGGAGCGGGGGAGTGTCTATCAGCAAGCCAGGAAGCGTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT230135 WP_000362050.1 NZ_CP090141:c4453231-4452941 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT230135 NZ_CP124732:c4821117-4820869 [Pseudomonas sp. GM17]
ATGACCCATGTCCTTCTGTCCAACGTCGTTGCGAGCATTTCCGAACTCAAGAAAAACCCCATGGGCACTGTTGCGGCCGG
TGGCGGCTCCTCCGTGGCCATTCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGCCTGGAAGACATGGAACTGCTCGCCTTGTGCCGTGAGCGAGAGAACGACCCGACCGTCAGGGTTTCGCTCGAT
GACTTATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64