Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4454664..4455418 Replicon chromosome
Accession NZ_CP090137
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZK31_RS21275 Protein ID WP_133323219.1
Coordinates 4454664..4454975 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZK31_RS21280 Protein ID WP_001259009.1
Coordinates 4454972..4455418 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK31_RS21245 (4450322) 4450322..4451224 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LZK31_RS21250 (4451221) 4451221..4451856 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LZK31_RS21255 (4451853) 4451853..4452782 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LZK31_RS21260 (4452829) 4452829..4453119 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LZK31_RS21265 (4453120) 4453120..4453431 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LZK31_RS21270 (4453649) 4453649..4454578 + 930 WP_001127694.1 alpha/beta hydrolase -
LZK31_RS21275 (4454664) 4454664..4454975 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
LZK31_RS21280 (4454972) 4454972..4455418 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LZK31_RS21285 (4455433) 4455433..4456374 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LZK31_RS21290 (4456419) 4456419..4456856 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LZK31_RS21295 (4456853) 4456853..4457725 - 873 WP_000921423.1 virulence factor BrkB family protein -
LZK31_RS21300 (4457719) 4457719..4458318 - 600 WP_000965698.1 glucose-1-phosphatase -
LZK31_RS21305 (4458509) 4458509..4459312 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LZK31_RS21310 (4459346) 4459346..4460242 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T230116 WP_133323219.1 NZ_CP090137:4454664-4454975 [Salmonella enterica subsp. enterica serovar Goldcoast]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T230116 NZ_CP124702:3906847-3907254 [Klebsiella pneumoniae]
ATGACGCAACAATATGCCCCTTACAGGAAAGGAACGGTCTTAGCGCCTGTTGGCGGCAGCGATCATTTACATATCATTTG
TAATGATCCGGTTCACTACCCGATACATGGTTGCGACTGTGTTCTGGTAGTGAATATTTCTTCTGTTTATCCACCACCAG
CTTACAGTGACCCTGCATGTATCCTTCATGCAGGGGAGCATCCCTTTGTCTTCCATGACAGTTTCGTTTATTACGAAGAT
GCTATCGTTTGGAAAGTACCGAATGTTATTTCGCGAGAGCAGAGTGGAGAACTTACTCCTCACGCCGATATGGAAGAAAA
CGTACTTCAGAGGGTCTTGAGCGGTTTTGAAGCATCCGATTTCACTAATCCGAAGATATTAAAATTCTATAGGGCACACT
GCATTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT230116 WP_001259009.1 NZ_CP090137:4454972-4455418 [Salmonella enterica subsp. enterica serovar Goldcoast]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT230116 NZ_CP124702:3906281-3906850 [Klebsiella pneumoniae]
ATGTATAGCGAAAGCAAAACTGCGCAAATGGCTGGCTATCTGCTGCTTAAACGTGGTGGACGCATGGCATACATCAAGCT
CATGAAGTTGCTGTATCTTGCTGACAGGGAATACATGATCACTTACGGCGACTCCATGACTGGTGATCGTGCCGTATCCA
TGAATAATGGACCTGTTCTGTCAAGAACGTATGACCTGCTGAAATCAGGTAGCCCGGAGGAAGAATCTCCCTGGGATGAC
TGGATTGCCGGTGAGGCAGATTTTGAAGTGTCATTGAAGAAACGAGTTAACGGACTCGACGACGATGACGCATTCGATGA
GCTCAGCAAGGCAAACAAACGCATTCTTGATAAAGTATTTGACGAATATGGTCAGTACAAACGATTTGAGCTTTGTGATC
TGACACATCGAGTGTGCGCTGAATGGCAAAATCCGCATGGTTCATCAGTTCCCATCAGCCCTAAAGATATTCTTATGGCT
GGGGGTAAAAGTGAATCAGAAGCTGATGAGCTAATTCGCCATATGCGTGAGAGAGATGCACTCAAACAGTTCAGCAGGCA
ACTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References