Detailed information of TA system TA230095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4452831..4453433
• Replicon: chromosome
• Accession: NZ_CP090133
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL07

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LZK29_RS21265
• Protein ID: WP_001159630.1
• Coordinates: 4453122..4453433 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LZK29_RS21260
• Protein ID: WP_000362050.1
• Coordinates: 4452831..4453121 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK29_RS21245 (4450324)	4450324..4451226	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LZK29_RS21250 (4451223)	4451223..4451858	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LZK29_RS21255 (4451855)	4451855..4452784	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LZK29_RS21260 (4452831)	4452831..4453121	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LZK29_RS21265 (4453122)	4453122..4453433	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LZK29_RS21270 (4453651)	4453651..4454580	+	930	WP_001127694.1	alpha/beta hydrolase	-
LZK29_RS21275 (4454666)	4454666..4454977	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
LZK29_RS21280 (4454974)	4454974..4455420	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LZK29_RS21285 (4455435)	4455435..4456376	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LZK29_RS21290 (4456421)	4456421..4456858	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
LZK29_RS21295 (4456855)	4456855..4457727	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LZK29_RS21300 (4457721)	4457721..4458320	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T230095 WP_001159630.1 NZ_CP090133:c4453433-4453122 [Salmonella enterica subsp. enterica serovar Goldcoast]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T230095 NZ_CP124697:8873-9196 [Klebsiella pneumoniae]
ATGAACTATCTGGAGTTTGTTGAAACCAGCGCTTTCAGTGGACTGCGTAAGGAACTCATGGATGATGATGAATTCCGCGA
ACTGCAGACCTATTTACTGGAAGCCCATGATCGGGGTGACACCATCAGTCATACCGGTGGATGCAGGAAGATTCGCTGGG
GTCGCCCGGGGATGGGTAAGCGAGGTGGCGTCAGGGTGATTTACTACGTTCGTCTTGCCAGCGGCAGACTGTATCTGCTG
CTGATATACCCGAAGAATGCGAAAGATGAGCTCAGCGAGAAAGAAAAAGCCGTTATGAAGGCATTAACACAGCAGCTGAA
GTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT230095 WP_000362050.1 NZ_CP090133:c4453121-4452831 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT230095 NZ_CP124697:9245-9547 [Klebsiella pneumoniae]
ATGGAAAAGAAACTTTTTGATGCCCTGATCAGCAGCATGGAGGAAATGGTGGCCATTGAAAATGGCCAGATCCAGCCCGC
TGCAGAACAGGTTCACCGCCATACACTGCCGGATGTGAAAGCCATTCGTAAACATGCCGGCATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGGGCCAGCGTTGACCTTGTTCGCAGCTGGGAACAGCAACGGCGTGTTCCGTCGGGTATTGCGCTGAAA
ATGCTCTGCCTCATCGAGCGTGAGCCTGCACTGATTAATACGTTGCGTGGTATTCACGTCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64