Detailed information of TA system TA230051

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2458447..2458773
• Replicon: chromosome
• Accession: NZ_CP090125
• Organism: Bacillus subtilis strain Bs96

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: LXE94_RS13170
• Protein ID: WP_004398662.1
• Coordinates: 2458447..2458626 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2458550..2458773 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE94_RS13160 (2457673)	2457673..2457810	-	138	WP_021480099.1	hypothetical protein	-
LXE94_RS13165 (2457852)	2457852..2458301	-	450	WP_032722171.1	phage portal protein	-
LXE94_RS13170 (2458447)	2458447..2458626	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
- (2458550)	2458550..2458773	-	224	NuclAT_0	-	Antitoxin
- (2458550)	2458550..2458773	-	224	NuclAT_0	-	Antitoxin
- (2458550)	2458550..2458773	-	224	NuclAT_0	-	Antitoxin
- (2458550)	2458550..2458773	-	224	NuclAT_0	-	Antitoxin
LXE94_RS13175 (2459007)	2459007..2459096	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
LXE94_RS13180 (2459350)	2459350..2459793	-	444	WP_003229930.1	phage tail tube protein	-
LXE94_RS13185 (2459796)	2459796..2461196	-	1401	WP_003229929.1	phage tail sheath family protein	-
LXE94_RS13190 (2461197)	2461197..2461388	-	192	WP_010886574.1	hypothetical protein	-
LXE94_RS13195 (2461385)	2461385..2461822	-	438	WP_003229927.1	hypothetical protein	-
LXE94_RS13200 (2461835)	2461835..2462338	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
LXE94_RS13205 (2462335)	2462335..2462697	-	363	WP_003229925.1	YqbH/XkdH family protein	-
LXE94_RS13210 (2462694)	2462694..2463089	-	396	WP_004398566.1	DUF3199 family protein	-
LXE94_RS13215 (2463093)	2463093..2463404	-	312	WP_257986089.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2426471..2485346	58875

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T230051 WP_004398662.1 NZ_CP090125:2458447-2458626 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T230051 NZ_CP124666:c5457066-5456788 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCTGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Nucleotide

• Length: 224 bp

>AT230051 NZ_CP090125:c2458773-2458550 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACAACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCATAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAGAAGAAACTACCCTTTAATA
GGAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin