Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 44713..45298 Replicon chromosome
Accession NZ_CP090067
Organism Acinetobacter sp. SH20PTE14

Toxin (Protein)


Gene name higB Uniprot ID A0A3F3L0E6
Locus tag LXF01_RS00195 Protein ID WP_002126330.1
Coordinates 44978..45298 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LXF01_RS00190 Protein ID WP_004676016.1
Coordinates 44713..44985 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF01_RS00165 (LXF01_00165) 40225..41910 + 1686 WP_233944769.1 dihydroxy-acid dehydratase -
LXF01_RS00170 (LXF01_00170) 42062..43384 + 1323 WP_111885146.1 hypothetical protein -
LXF01_RS00175 (LXF01_00175) 43365..43652 + 288 WP_078191648.1 chorismate mutase -
LXF01_RS00180 (LXF01_00180) 43941..44117 + 177 Protein_30 transposase -
LXF01_RS00185 (LXF01_00185) 44138..44518 + 381 WP_168417344.1 hypothetical protein -
LXF01_RS00190 (LXF01_00190) 44713..44985 - 273 WP_004676016.1 NadS family protein Antitoxin
LXF01_RS00195 (LXF01_00195) 44978..45298 - 321 WP_002126330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXF01_RS00200 (LXF01_00200) 45455..46063 - 609 WP_078194113.1 NAD(P)H-dependent oxidoreductase -
LXF01_RS00205 (LXF01_00205) 46162..47073 + 912 WP_233944771.1 LysR family transcriptional regulator -
LXF01_RS00210 (LXF01_00210) 47453..48190 + 738 WP_180049573.1 sulfite exporter TauE/SafE family protein -
LXF01_RS00215 (LXF01_00215) 48200..49102 - 903 WP_233944772.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12191.98 Da        Isoelectric Point: 7.9834

>T230000 WP_002126330.1 NZ_CP090067:c45298-44978 [Acinetobacter sp. SH20PTE14]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVNEDDQIFFLVAY
PKSVKDNLTDKETAILRQLVKEQFHG

Download         Length: 321 bp

>T230000 NZ_CP124658:1840448-1841035 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10178.56 Da        Isoelectric Point: 7.3200

>AT230000 WP_004676016.1 NZ_CP090067:c44985-44713 [Acinetobacter sp. SH20PTE14]
MDNNLFDDLVASIKEAGAIKRKEIQASRTTELELPDIKEVREKTGLSQSEFAARLHISHRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT230000 NZ_CP124658:1841102-1841956 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAGATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3F3L0E6

Antitoxin

Source ID Structure

References