Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 30383..31040 Replicon chromosome
Accession NZ_CP090065
Organism Pectobacterium polonicum strain BY21311

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LW347_RS00135 Protein ID WP_258883653.1
Coordinates 30669..31040 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LW347_RS00130 Protein ID WP_103862387.1
Coordinates 30383..30682 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW347_RS00110 (LW347_00110) 25617..26624 + 1008 WP_258883650.1 nucleoside hydrolase -
LW347_RS00115 (LW347_00115) 26624..27601 + 978 WP_005976707.1 ABC transporter permease -
LW347_RS00120 (LW347_00120) 27598..28506 + 909 WP_258883651.1 ABC transporter permease -
LW347_RS00125 (LW347_00125) 28546..30345 + 1800 WP_258883652.1 ABC transporter ATP-binding protein -
LW347_RS00130 (LW347_00130) 30383..30682 - 300 WP_103862387.1 XRE family transcriptional regulator Antitoxin
LW347_RS00135 (LW347_00135) 30669..31040 - 372 WP_258883653.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LW347_RS00140 (LW347_00140) 31271..31768 + 498 WP_137741840.1 GNAT family N-acetyltransferase -
LW347_RS00145 (LW347_00145) 31968..32225 - 258 WP_258883654.1 DUF1471 domain-containing protein -
LW347_RS00150 (LW347_00150) 32398..33198 - 801 WP_258883655.1 aliphatic sulfonates ABC transporter ATP-binding protein -
LW347_RS00155 (LW347_00155) 33195..33989 - 795 WP_137741837.1 aliphatic sulfonate ABC transporter permease SsuC -
LW347_RS00160 (LW347_00160) 34000..35142 - 1143 WP_258883656.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14102.05 Da        Isoelectric Point: 5.2755

>T229985 WP_258883653.1 NZ_CP090065:c31040-30669 [Pectobacterium polonicum]
MAWKIVTRALFDTWFDEQNEAVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IILCAGDKKGEDEKLFYERMIKIADAEFTSHLISQGVKEDGDA

Download         Length: 372 bp

>T229985 NZ_CP124655:1423347-1423637 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGATAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11034.05 Da        Isoelectric Point: 10.6442

>AT229985 WP_103862387.1 NZ_CP090065:c30682-30383 [Pectobacterium polonicum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVDNDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT229985 NZ_CP124655:1423051-1423350 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References