Detailed information of TA system TA229927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1415486..1416146
• Replicon: chromosome
• Accession: NZ_CP090028
• Organism: Serratia ureilytica strain W051

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LSG14_RS06640
• Protein ID: WP_197782341.1
• Coordinates: 1415486..1415839 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8G2G5Z5
• Locus tag: LSG14_RS06645
• Protein ID: WP_016927038.1
• Coordinates: 1415844..1416146 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSG14_RS06620	1411577..1411942	+	366	WP_033643759.1	diacylglycerol kinase	-
LSG14_RS06625	1412045..1412944	+	900	WP_033651879.1	LysR family transcriptional regulator	-
LSG14_RS06630	1412919..1413725	-	807	WP_197755855.1	substrate-binding domain-containing protein	-
LSG14_RS06635	1413752..1415047	-	1296	WP_033643756.1	MFS transporter	-
LSG14_RS06640	1415486..1415839	+	354	WP_197782341.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LSG14_RS06645	1415844..1416146	+	303	WP_016927038.1	XRE family transcriptional regulator	Antitoxin
LSG14_RS06650	1416560..1417768	+	1209	WP_108681456.1	aldose 1-epimerase family protein	-
LSG14_RS06660	1418374..1419492	+	1119	WP_016927040.1	branched-chain amino acid ABC transporter substrate-binding protein	-
LSG14_RS06665	1419617..1420531	+	915	WP_033643752.1	branched-chain amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13461.45 Da
• Isoelectric Point: 9.0587

>T229927 WP_197782341.1 NZ_CP090028:1415486-1415839 [Serratia ureilytica]
VWEIKTTDAFDHGFRSLSDADRAGVLAALMVLREKGPGLPRPYVDMVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T229927 NZ_CP124641:3547961-3548539 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCACTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11093.96 Da
• Isoelectric Point: 6.4738

>AT229927 WP_016927038.1 NZ_CP090028:1415844-1416146 [Serratia ureilytica]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT229927 NZ_CP124641:3547319-3547873 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAAGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA