Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 300362..301092 Replicon chromosome
Accession NZ_CP090028
Organism Serratia ureilytica strain W051

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag LSG14_RS01415 Protein ID WP_004937033.1
Coordinates 300781..301092 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LSG14_RS01410 Protein ID WP_182074436.1
Coordinates 300362..300784 (-) Length 141 a.a.

Genomic Context

LSG14_RS01395LSG14_RS01400LSG14_RS01405LSG14_RS01410LSG14_RS01415LSG14_RS01420LSG14_RS01425LSG14_RS01430LSG14_RS01435LSG14_RS01440LSG14_RS01445
Location: 296345..297085 (741 bp)
Type: Others
Protein ID: WP_047573565.1
Location: 297173..298387 (1215 bp)
Type: Others
Protein ID: WP_233788328.1
Location: 298439..300355 (1917 bp)
Type: Others
Protein ID: WP_033644486.1
Location: 300362..300784 (423 bp)
Type: Antitoxin
Protein ID: WP_182074436.1
Location: 300781..301092 (312 bp)
Type: Toxin
Protein ID: WP_004937033.1
Location: 301387..301659 (273 bp)
Type: Others
Protein ID: WP_004937034.1
Location: 301656..302510 (855 bp)
Type: Others
Protein ID: WP_015379177.1
Location: 302638..303099 (462 bp)
Type: Others
Protein ID: WP_016930212.1
Location: 303255..303542 (288 bp)
Type: Others
Protein ID: WP_004937038.1
Location: 303566..304999 (1434 bp)
Type: Others
Protein ID: WP_004937039.1
Location: 305052..305777 (726 bp)
Type: Others
Protein ID: WP_004937040.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LSG14_RS01395296345..297085+741WP_047573565.1KDGP aldolase family protein-
LSG14_RS01400297173..298387+1215WP_233788328.1lactonase family protein-
LSG14_RS01405298439..300355+1917WP_033644486.1PRD domain-containing protein-
LSG14_RS01410300362..300784-423WP_182074436.1helix-turn-helix domain-containing proteinAntitoxin
LSG14_RS01415300781..301092-312WP_004937033.1type II toxin-antitoxin system HigB family toxinToxin
LSG14_RS01420301387..301659-273WP_004937034.1PTS phosphocarrier protein NPr-
LSG14_RS01425301656..302510-855WP_015379177.1RNase adapter RapZ-
LSG14_RS01430302638..303099-462WP_016930212.1PTS IIA-like nitrogen regulatory protein PtsN-
LSG14_RS01435303255..303542-288WP_004937038.1ribosome hibernation promoting factor-
LSG14_RS01440303566..304999-1434WP_004937039.1RNA polymerase factor sigma-54-
LSG14_RS01445305052..305777-726WP_004937040.1LPS export ABC transporter ATP-binding protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T229923 WP_004937033.1 NZ_CP090028:c301092-300781 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T229923 NZ_CP124638:c6091368-6091075 [Pseudomonas aeruginosa]
ATGAACAAGACCAAGCTGAACATGCGGCCCTTCGATGCGGCCCACTACTTGAACAATGAGGAAGAGATGGCCGCCTACCT
CGACGTGATTCTGGAAGACAACGACCCGGCGCTGCTGGCCGTTGCTCTGGGCGATATCGCCCGTGCACGCGGCATGACCG
AGCTGGCCCGTAAAACCGGCCTGTCGCGTGAGAGCCTGTACAAGAGCCTGTCCGGCGAGCGCGTGCCGAGCACTGAAACG
CTGCTGAAGGTCATTCATGCCCTGGGCTTCAAGCTGACGGTCTCCGCCGCTTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15770.10 Da        Isoelectric Point: 5.2060

>AT229923 WP_182074436.1 NZ_CP090028:c300784-300362 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYRDALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT229923 NZ_CP124638:c6091659-6091369 [Pseudomonas aeruginosa]
ATGTACTCCATTATCGAAACCGAGGCGTTCAGCGACTGGCTGAACGGCCTGAAAGATACGGTCACCCGCATGCGCTTGAT
CAAGCGTTTGCAGCGCGCAAGCCTGGGCAACCTGGGCGATGTGAAGCCGGTTGGTGAAGGGGTGTATGAAATGCGCGAGT
TTTTCGGCCCTGGCTGGCGCATGTACTACGTGCAGCAGGGCGATGTGCTGCTGATCATGCTGGGCGGTGGCGACAAATCC
AGCCAGCAGCGTGATATCGAGCGGGCAATTCAGTTGTCCAAGGAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A8B4GR63

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References