Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2452768..2453291 Replicon chromosome
Accession NZ_CP090001
Organism Staphylococcus aureus strain RN6390

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag LV622_RS12180 Protein ID WP_000074048.1
Coordinates 2452768..2453034 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LV622_RS12185 Protein ID WP_000587616.1
Coordinates 2453034..2453291 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV622_RS12160 (LV622_12160) 2448075..2449262 - 1188 WP_000026194.1 MFS transporter -
LV622_RS12165 (LV622_12165) 2449658..2450434 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
LV622_RS12170 (LV622_12170) 2450427..2451089 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
LV622_RS12175 (LV622_12175) 2451337..2452413 - 1077 WP_001076671.1 M42 family metallopeptidase -
LV622_RS12180 (LV622_12180) 2452768..2453034 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
LV622_RS12185 (LV622_12185) 2453034..2453291 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LV622_RS12190 (LV622_12190) 2453650..2454105 + 456 WP_000732082.1 DUF1307 domain-containing protein -
LV622_RS12195 (LV622_12195) 2454273..2455850 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
LV622_RS12200 (LV622_12200) 2456045..2456794 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
LV622_RS12205 (LV622_12205) 2457018..2458211 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T229907 WP_000074048.1 NZ_CP090001:c2453034-2452768 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T229907 NZ_CP124632:3905362-3905661 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCTAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATTCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT229907 WP_000587616.1 NZ_CP090001:c2453291-2453034 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT229907 NZ_CP124632:3905658-3905948 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References