229905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2421267..2421451 Replicon chromosome
Accession NZ_CP090001
Organism Staphylococcus aureus strain RN6390

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag LV622_RS12040 Protein ID WP_000482650.1
Coordinates 2421344..2421451 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2421267..2421327 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV622_RS12025 (LV622_12025) 2416797..2416964 - 168 WP_001790576.1 hypothetical protein -
LV622_RS12030 (LV622_12030) 2417195..2418928 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
LV622_RS12035 (LV622_12035) 2418953..2420716 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2421267..2421327 + 61 - - Antitoxin
LV622_RS12040 (LV622_12040) 2421344..2421451 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
LV622_RS12045 (LV622_12045) 2421585..2421971 - 387 WP_000779358.1 flippase GtxA -
LV622_RS12050 (LV622_12050) 2422239..2423381 + 1143 WP_001176863.1 glycerate kinase -
LV622_RS12055 (LV622_12055) 2423441..2424100 + 660 WP_000831298.1 membrane protein -
LV622_RS12060 (LV622_12060) 2424282..2425493 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
LV622_RS12065 (LV622_12065) 2425616..2426089 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T229905 WP_000482650.1 NZ_CP090001:c2421451-2421344 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T229905 NZ_CP124632:2340528-2341115 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 61 bp

>AT229905 NZ_CP090001:2421267-2421327 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8


Antitoxin

Download structure file

References