Detailed information of TA system TA229899

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1837992..1838174
• Replicon: chromosome
• Accession: NZ_CP090001
• Organism: Staphylococcus aureus strain RN6390

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LV622_RS08895
• Protein ID: WP_001801861.1
• Coordinates: 1837992..1838087 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1838115..1838174 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LV622_RS08855 (LV622_08855)	1833652..1834278	+	627	WP_000669046.1	hypothetical protein	-
LV622_RS08860 (LV622_08860)	1834319..1834663	+	345	WP_000627551.1	DUF3969 family protein	-
LV622_RS08865 (LV622_08865)	1834761..1835312	+	552	WP_000414205.1	hypothetical protein	-
LV622_RS08870 (LV622_08870)	1835530..1836171	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
LV622_RS08875 (LV622_08875)	1836285..1836470	-	186	WP_000809857.1	hypothetical protein	-
LV622_RS08880 (LV622_08880)	1836472..1836648	-	177	WP_000375476.1	hypothetical protein	-
LV622_RS08885 (LV622_08885)	1836659..1837042	-	384	WP_000070812.1	hypothetical protein	-
LV622_RS08890 (LV622_08890)	1837646..1837789	-	144	WP_001549059.1	transposase	-
LV622_RS08895 (LV622_08895)	1837992..1838087	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1838115..1838174	-	60	-	-	Antitoxin
LV622_RS08900 (LV622_08900)	1838210..1838311	+	102	WP_001791893.1	hypothetical protein	-
LV622_RS08905 (LV622_08905)	1838289..1838465	-	177	Protein_1753	transposase	-
LV622_RS08910 (LV622_08910)	1838659..1839036	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1831092..1871263	40171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T229899 WP_001801861.1 NZ_CP090001:1837992-1838087 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T229899 NZ_CP124626:c4254753-4254175 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAGCGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGAACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT229899 NZ_CP090001:c1838174-1838115 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin