Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1832032..1832677 Replicon chromosome
Accession NC_011060
Organism Pelodictyon phaeoclathratiforme BU-1

Toxin (Protein)


Gene name higB Uniprot ID B4SB12
Locus tag PPHA_RS08535 Protein ID WP_012508445.1
Coordinates 1832032..1832358 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PPHA_RS08540 Protein ID WP_012508446.1
Coordinates 1832351..1832677 (+) Length 109 a.a.

Genomic Context

PPHA_RS08485PPHA_RS08535PPHA_RS08540PPHA_RS08555PPHA_RS08490PPHA_RS08495PPHA_RS08500PPHA_RS08505PPHA_RS08510PPHA_RS15115PPHA_RS08520PPHA_RS08525PPHA_RS08530PPHA_RS08545PPHA_RS08550PPHA_RS08560PPHA_RS08565PPHA_RS08570
Location: 1827057..1827290 (234 bp)
Type: Others
Protein ID: WP_041526794.1
Location: 1832032..1832358 (327 bp)
Type: Toxin
Protein ID: WP_012508445.1
Location: 1832351..1832677 (327 bp)
Type: Antitoxin
Protein ID: WP_012508446.1
Location: 1834336..1835010 (675 bp)
Type: Others
Protein ID: WP_041526494.1
Location: 1827457..1827669 (213 bp)
Type: Others
Protein ID: WP_041526492.1
Location: 1827650..1827931 (282 bp)
Type: Others
Protein ID: WP_012508438.1
Location: 1828073..1828300 (228 bp)
Type: Others
Protein ID: WP_012508439.1
Location: 1828350..1828853 (504 bp)
Type: Others
Protein ID: WP_012508440.1
Location: 1828860..1829138 (279 bp)
Type: Others
Protein ID: WP_012508441.1
Location: 1829228..1830236 (1009 bp)
Type: Others
Protein ID: Protein_1668
Location: 1830494..1830883 (390 bp)
Type: Others
Protein ID: WP_012508442.1
Location: 1830880..1831110 (231 bp)
Type: Others
Protein ID: WP_012508443.1
Location: 1831362..1831613 (252 bp)
Type: Others
Protein ID: WP_012508444.1
Location: 1832737..1832918 (182 bp)
Type: Others
Protein ID: Protein_1674
Location: 1833005..1834078 (1074 bp)
Type: Others
Protein ID: WP_012508448.1
Location: 1835039..1836088 (1050 bp)
Type: Others
Protein ID: WP_012508450.1
Location: 1836202..1836744 (543 bp)
Type: Others
Protein ID: WP_012508451.1
Location: 1836756..1837178 (423 bp)
Type: Others
Protein ID: WP_041526495.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PPHA_RS084851827057..1827290+234WP_041526794.1hypothetical protein-
PPHA_RS084901827457..1827669-213WP_041526492.1hypothetical protein-
PPHA_RS084951827650..1827931-282WP_012508438.1BrnT family toxin-
PPHA_RS085001828073..1828300-228WP_012508439.1CopG family transcriptional regulator-
PPHA_RS085051828350..1828853-504WP_012508440.1GNAT family N-acetyltransferase-
PPHA_RS085101828860..1829138-279WP_012508441.1DUF1778 domain-containing protein-
PPHA_RS151151829228..1830236-1009Protein_1668ABC transporter permease-
PPHA_RS085201830494..1830883-390WP_012508442.1type II toxin-antitoxin system VapC family toxin-
PPHA_RS085251830880..1831110-231WP_012508443.1hypothetical protein-
PPHA_RS085301831362..1831613-252WP_012508444.1UPF0175 family protein-
PPHA_RS085351832032..1832358+327WP_012508445.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PPHA_RS085401832351..1832677+327WP_012508446.1helix-turn-helix domain-containing proteinAntitoxin
PPHA_RS085451832737..1832918-182Protein_1674ABC transporter ATP-binding protein-
PPHA_RS085501833005..1834078-1074WP_012508448.1metallophosphoesterase family protein-
PPHA_RS085551834336..1835010+675WP_041526494.1tRNA (guanosine(18)-2'-O)-methyltransferase TrmH-
PPHA_RS085601835039..1836088-1050WP_012508450.1DUF4332 domain-containing protein-
PPHA_RS085651836202..1836744-543WP_012508451.1hypothetical protein-
PPHA_RS085701836756..1837178-423WP_041526495.1rRNA maturation RNase YbeY-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1829670..184628116611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-96)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12497.78 Da        Isoelectric Point: 9.7065

>T22985 WP_012508445.1 NC_011060:1832032-1832358 [Pelodictyon phaeoclathratiforme BU-1]
MAYRIDYFHPRILKEIEGWPESIKTDYARIVELLMDYGHDLRMPCSRAMGNGLFEIRPKGKDGIGRALYCFQTGELIIIP
HAFIKKSQATPRKEMVLALKRMKEVING

Download         Length: 327 bp

>T22985 NC_011060:1832032-1832358 [Pelodictyon phaeoclathratiforme BU-1]
ATGGCTTATCGAATTGACTATTTTCACCCTCGGATACTGAAAGAGATTGAGGGTTGGCCGGAGTCGATCAAGACTGATTA
CGCACGCATTGTTGAATTGCTTATGGATTACGGCCATGATTTGCGTATGCCCTGTTCACGGGCAATGGGAAATGGCTTGT
TTGAGATTCGGCCCAAGGGAAAGGATGGCATTGGAAGAGCACTCTACTGTTTTCAGACAGGAGAGCTAATCATTATCCCG
CACGCATTTATCAAGAAATCGCAAGCGACGCCACGAAAAGAGATGGTGCTCGCGCTTAAAAGAATGAAGGAGGTAATCAA
TGGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12128.11 Da        Isoelectric Point: 10.0517

>AT22985 WP_012508446.1 NC_011060:1832351-1832677 [Pelodictyon phaeoclathratiforme BU-1]
MDDLKYQPVEHNHEEFLRKAMVNKEFKAGYEALGPKYALIRELLAARQRSGMTQEAVALKIGTSKSAISRLESGSKHTPS
VATLRKYADAVGCELEIKLIKKKEPQKI

Download         Length: 327 bp

>AT22985 NC_011060:1832351-1832677 [Pelodictyon phaeoclathratiforme BU-1]
ATGGATGATCTCAAATACCAGCCTGTGGAGCACAATCACGAAGAATTTCTCCGCAAGGCAATGGTAAATAAAGAATTTAA
AGCGGGGTATGAGGCTCTTGGACCGAAGTATGCCCTGATACGGGAACTCCTTGCCGCCCGCCAGCGCTCAGGCATGACGC
AAGAAGCTGTTGCTCTGAAAATAGGCACGTCAAAAAGTGCCATCTCCAGACTGGAATCCGGCAGCAAGCATACCCCCTCT
GTTGCCACGCTGAGGAAATACGCCGATGCAGTTGGCTGCGAACTGGAAATCAAACTGATCAAAAAAAAGGAACCGCAAAA
GATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB4SB12

Antitoxin

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Source
ID
Structure
No matching records found

References