Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 357591..358237 Replicon chromosome
Accession NZ_CP089986
Organism Klebsiella pneumoniae strain LZKP00001

Toxin (Protein)


Gene name higB Uniprot ID A0A483PC41
Locus tag LUA09_RS01655 Protein ID WP_004216295.1
Coordinates 357591..357938 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LUA09_RS01660 Protein ID WP_002920557.1
Coordinates 357938..358237 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUA09_RS01645 (LUA09_01645) 353517..354950 + 1434 WP_004889438.1 glycogen synthase GlgA -
LUA09_RS01650 (LUA09_01650) 354968..357415 + 2448 WP_002920561.1 glycogen phosphorylase -
LUA09_RS01655 (LUA09_01655) 357591..357938 + 348 WP_004216295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUA09_RS01660 (LUA09_01660) 357938..358237 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LUA09_RS01665 (LUA09_01665) 358300..359808 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LUA09_RS01670 (LUA09_01670) 360013..360342 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LUA09_RS01675 (LUA09_01675) 360393..361223 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LUA09_RS01680 (LUA09_01680) 361273..362031 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 5.6749

>T229845 WP_004216295.1 NZ_CP089986:357591-357938 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCADNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T229845 NZ_CP124543:c5519720-5519358 [Halotia branconii CENA392]
ATGCAGAGTGATGAGGCGGTTATAATTCGGTTCTCTGATGAATTTGAGGAGGAACTTTACAGACTTTCCAAAAGATTTCG
CAATATTCGCTCTGATGTGCAGCCGATTATTGAACAATTACAACAAGGAAATATTATTGGAGATAGAATTGCAGGAATAG
GCGAGGAGTATATTGTTTATAAGGTGAGAGTTCGCAACAGTAATATTCAAAAAGGTAAAAGTGCTGGATATTGTTTAATT
TATCAAGTTGAGTCACCTACAACTATTTTGCTATTAACAATTTATTCTAAATCGGATCGAGAAGATATTGGTACAAATGA
AATTCGAGATATTGTAGCTGATTTTTATCATAAACAAGATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT229845 WP_002920557.1 NZ_CP089986:357938-358237 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT229845 NZ_CP124543:c5519275-5519018 [Halotia branconii CENA392]
ATGAAAGCGATTGAAGTTACTGGTAAAATTGATGCTCAAGGAAATTTAGTTTTGGATGAGCCAATTCTGGGAACGACTTA
CCCTCATCAGGTGCGGGTAATTGTCTTAGTCCCAGAACAGACAGAAGCAGAAGAGGTTGACCCTGATGATACACCTCTTG
AAGAGATTAAAGCCAGCTTAAGGAGAGCTTTGCAGCAAGCAAAAGCAGGACAGCGTTTACCACTATCCCAAATGTGGGAG
GGAATTGATGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483PC41

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References