Detailed information of TA system TA229836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5790418..5790995
• Replicon: chromosome
• Accession: NZ_CP089980
• Organism: Fulvivirga sp. SW1-E11

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: LVD15_RS24330
• Protein ID: WP_233777788.1
• Coordinates: 5790714..5790995 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LVD15_RS24325
• Protein ID: WP_233777787.1
• Coordinates: 5790418..5790714 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVD15_RS24310 (LVD15_24310)	5786044..5788446	-	2403	WP_233777784.1	TonB-dependent receptor	-
LVD15_RS24315 (LVD15_24315)	5788576..5789565	+	990	WP_233777785.1	AraC family transcriptional regulator	-
LVD15_RS24320 (LVD15_24320)	5789620..5790117	-	498	WP_233777786.1	DUF4468 domain-containing protein	-
LVD15_RS24325 (LVD15_24325)	5790418..5790714	-	297	WP_233777787.1	HigA family addiction module antitoxin	Antitoxin
LVD15_RS24330 (LVD15_24330)	5790714..5790995	-	282	WP_233777788.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LVD15_RS24335 (LVD15_24335)	5791310..5792107	-	798	WP_233777790.1	hypothetical protein	-
LVD15_RS24340 (LVD15_24340)	5792315..5792800	-	486	WP_233777791.1	hypothetical protein	-
LVD15_RS24345 (LVD15_24345)	5793094..5795604	-	2511	WP_233777792.1	zinc-dependent metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (11-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-66)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11042.65 Da
• Isoelectric Point: 8.9359

>T229836 WP_233777788.1 NZ_CP089980:c5790995-5790714 [Fulvivirga sp. SW1-E11]
MIESFGCKHTEKVWNGVWTKKWSDEVANNALRKMFMINAAGDIQDLKIPPSNRLHKLKGNMKEYWAISINDQWRIIFQWS
NTNAYDVQIIDYH

Nucleotide

• Length: 282 bp

>T229836 NZ_CP124536:c119743-119348 [Fuscovulum sp. YMD61]
ATGAGCGCTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGATGGCCCGAAGGCCGATCGCGCCGAGGTTAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTCCTGAACGAGACGCTGGTGAACTGTCGCCGCAAGGCTGGCATGAGCT
GGGAGGAAGCAGGGGCGTTTCTTGAGAGCATTCGTGCCTTGTGCCCCGTCGAAGACCTGACCATTCAGACCCACGACGTC
GGCCGCGCCTTGGCGGAACGCTACAGCTTCTCGATCTACGACGCCATGATCATGGCCAGCGCTTTGGTTGCGGGCTGCAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTCGAAGGCCAGCTTCGCATCATCAACCCTTTTGCGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11517.13 Da
• Isoelectric Point: 7.1651

>AT229836 WP_233777787.1 NZ_CP089980:c5790714-5790418 [Fulvivirga sp. SW1-E11]
MLKNNIHPGEILKYEFLDPMNLSSYKLSKELGIQQTRISQIIKGKRSVTADTAIRLSKFFGTTEEFWMNLQCEYDLRNAH
SEKDNEFNKIQKFEIDQA

Nucleotide

• Length: 297 bp

>AT229836 NZ_CP124536:c119960-119733 [Fuscovulum sp. YMD61]
ATGCAGGTCGCAAAATGGGGCAACTCGCTTGCCGTCCGTTTACCCGCTGAGCTTGTCCGGGAACTTGGCCTCAAGGAAGG
CGATCAGATCGACCTGGTCAAGGACGACGGCCAGGTCAGAGTCCGTCGTCTGGCGCGCGCGGATGAGGTGCTGACGGGTC
TGCGCCGCTTCCGGGGCAAGCTGCCCGCTGCGGGACGCCTGAGCCGCGATGACGCGCATGAGCGCTGA