Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 171621..172137 Replicon plasmid pORIO1
Accession NZ_CP089967
Organism Cereibacter azotoformans strain ORIO

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ORIO_RS20290 Protein ID WP_011910969.1
Coordinates 171871..172137 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ORIO_RS20285 Protein ID WP_011910970.1
Coordinates 171621..171890 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORIO_RS20260 (ORIO_20260) 167068..167148 + 81 Protein_137 recombinase family protein -
ORIO_RS20265 (ORIO_20265) 167182..168509 - 1328 Protein_138 IS256 family transposase -
ORIO_RS20270 (ORIO_20270) 168605..168733 + 129 Protein_139 helix-turn-helix domain-containing protein -
ORIO_RS20275 (ORIO_20275) 168826..170031 - 1206 WP_238823574.1 sodium/glutamate symporter -
ORIO_RS20280 (ORIO_20280) 170429..171016 + 588 Protein_141 Tn3 family transposase -
ORIO_RS20285 (ORIO_20285) 171621..171890 + 270 WP_011910970.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ORIO_RS20290 (ORIO_20290) 171871..172137 + 267 WP_011910969.1 Txe/YoeB family addiction module toxin Toxin
ORIO_RS20295 (ORIO_20295) 172395..172619 + 225 WP_011910967.1 hypothetical protein -
ORIO_RS20300 (ORIO_20300) 172616..173020 + 405 WP_011910966.1 type II toxin-antitoxin system death-on-curing family toxin -
ORIO_RS20305 (ORIO_20305) 173118..173177 - 60 Protein_146 helix-turn-helix domain-containing protein -
ORIO_RS20310 (ORIO_20310) 173394..173573 + 180 WP_145109290.1 hypothetical protein -
ORIO_RS23975 173732..173854 + 123 WP_275055971.1 hypothetical protein -
ORIO_RS20315 (ORIO_20315) 173876..174799 - 924 WP_238823575.1 DMT family transporter -
ORIO_RS20320 (ORIO_20320) 174919..175674 - 756 WP_238823576.1 AraC family transcriptional regulator -
ORIO_RS20325 (ORIO_20325) 175950..176129 - 180 WP_238823577.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - glf / glf 1..309984 309984
- flank IS/Tn - - 167182..167322 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10329.63 Da        Isoelectric Point: 9.5467

>T229818 WP_011910969.1 NZ_CP089967:171871-172137 [Cereibacter azotoformans]
MKLIFSDRAWDDYHHWHQTDATIFERLNGLIKEASRQPFRGTGKPEPLKGDLSGWWSRRLTGEHRLVYRVSGSGVTQALE
IAQCRYHY

Download         Length: 267 bp

>T229818 NZ_CP124522:4496464-4496775 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9841.06 Da        Isoelectric Point: 4.5069

>AT229818 WP_011910970.1 NZ_CP089967:171621-171890 [Cereibacter azotoformans]
MNILTYTDARKHLKSVMDSAIHDKEETVITRAGQEAVVVVGKEEWDAIQATLHLLSSPVNAARLRESIAQLNAGQGTERD
LIEDETDIL

Download         Length: 270 bp

>AT229818 NZ_CP124522:4496772-4497218 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References