229809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3728978..3729575 Replicon chromosome
Accession NZ_CP089959
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag LVQ74_RS18210 Protein ID WP_004142563.1
Coordinates 3729258..3729575 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag LVQ74_RS18205 Protein ID WP_004142561.1
Coordinates 3728978..3729265 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS18175 (LVQ74_18145) 3725185..3725433 + 249 WP_002893037.1 DUF1158 domain-containing protein -
LVQ74_RS18180 (LVQ74_18150) 3725451..3725792 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LVQ74_RS18185 (LVQ74_18155) 3725823..3726938 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
LVQ74_RS18190 (LVQ74_18160) 3727118..3727699 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
LVQ74_RS18195 (LVQ74_18165) 3727699..3728067 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
LVQ74_RS18200 (LVQ74_18170) 3728187..3728840 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
LVQ74_RS18205 (LVQ74_18175) 3728978..3729265 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
LVQ74_RS18210 (LVQ74_18180) 3729258..3729575 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ74_RS18215 (LVQ74_18185) 3729760..3730803 - 1044 WP_020802450.1 DUF2157 domain-containing protein -
LVQ74_RS18220 (LVQ74_18190) 3731470..3732336 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
LVQ74_RS18225 (LVQ74_18195) 3732445..3733872 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T229809 WP_004142563.1 NZ_CP089959:c3729575-3729258 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T229809 NZ_CP124522:c2444120-2443965 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT229809 WP_004142561.1 NZ_CP089959:c3729265-3728978 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT229809 NZ_CP124522:2444132-2444190 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References